Speaker
Description
In the human body, tubular structures are prevalent and exhibit various architectures, such as those found in the vascular and lymphatic systems. For instance, blood vessels can be viewed as tubular constructs with a specific diameter when considering their macroscopic shape. A closer examination reveals that these vessels consist of multiple layers, each composed of different extracellular matrix components and cell types. To replicate the hierarchical structure of blood vessels and enhance the biological function of tissue-engineered vascular models, it is essential to produce multi-layered tubular scaffolds.
This presentation will demonstrate how the combination of diverse materials and fabrication techniques can be utilized to create hierarchical tubular constructs with biomimetic architectures and adjustable mechanical properties. By integrating melt electrowriting and solution electrospinning, bi-layered tubular constructs can be generated for use as small diameter vascular grafts, featuring tunable mechanical properties and optimized cell orientation in co-culture and perfusion bioreactor setups. Additionally, combining melt electrowriting with the innovative additive manufacturing process of volumetric bioprinting enables the creation of defined fiber-reinforced hydrogel structures with customizable shapes. Traditional casting methods, when used in conjunction with fiber-based scaffolds, offer significant flexibility in material selection, which is particularly advantageous for developing drug-eluting structures. This presentation will showcase the latest advancements in these combined techniques.
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