Speaker
Description
The fabrication of biomimetic, multiscale, and multimaterial vascular networks remains a central challenge in tissue engineering and organ fabrication. We introduce an advanced light-based bioprinting framework that combines three advanced methodologies - Holographic Optical Tweezers Bioprinting (HOTB), multimaterial Digital Light Processing (DLP), and volumetric DLP bioprinting - to overcome the challenges of multiscale and multimaterial vascular fabrication. The HOTB based methodology enables precise, dynamic manipulation of individual cells and microgels within a photo-crosslinkable matrix, allowing for the active spatial organization of heterogeneous cellular components and microscale features. Complementarily, a custom multimaterial DLP platform facilitates rapid layer-by-layer polymerization of distinct bioinks through wavelength-selective photopolymerization, enabling spatially resolved deposition of materials with diverse mechanical and biological functionalities. Volumetric DLP complements these by enabling ultrafast, continuous fabrication of large-scale, perfusable vascular networks without layering artifacts. Together, these approaches offer a powerful, synergistic platform for generating hierarchically organized, cell-rich, and functionally zoned vascular systems.
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