Speaker
Description
Vascularization is critical for successful tissue regeneration, as it ensures adequate oxygen, nutrient delivery, and waste removal within engineered constructs. Without a functional vascular network, large or complex tissues are prone to necrosis and poor integration with host tissues. Rapid and stable vascular ingrowth is therefore essential for the survival and functionality of regenerated tissues. To this end, 3D bioprinting offers powerful tools to address vascularization challenges by enabling the spatially controlled deposition of cells, biomaterials, and growth factors. It allows the fabrication of pre-designed vascular networks or microchannel architectures that can guide endothelial cell organization and facilitate perfusion. These strategies not only improve tissue viability but also promote integration with host vasculature, making 3D bioprinting a promising approach for engineering thick, vascularized tissues for regenerative medicine. This talk will specifically discuss our recent efforts in developing a series of advanced vascular bioprinting strategies that tackle some of these problems and improve their capacities towards diverse applications in biomedicine. These platform technologies will likely provide new opportunities in areas from constructing functional tissues and microtissue models for promoting personalizable medicine, all the way to minimally invasive surgical implications.
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