Speaker
Description
Bioprinting technology holds tremendous potential for developing artificial tissues and organs that mimic the complexity of their native counterparts. However, despite considerable progress in the field, bioprinted tissues are structurally and functionally immature compared to their native counterparts. This limits their effectiveness as implants for regenerative medicine or predictive platforms for drug screening.
This talk will cover recent advances in my group on creating developmentally-inspired bioprinting strategies that can enhance the structure and function of bioprinted iPSC-derived heart tissues. The presentation will first describe the use of embedded bioprinting in granular support hydrogels to create tissue models that undergo predictable and programmable 4D shape-morphing driven by cell-generated forces. This section will also explore how such 4D shape-morphing behaviours can impact microarchitectural complexity of the developing tissues, including the emergence of global cell and ECM alignment. Next, the talk will describe more recent work on engineering phototunable granular support hydrogels that can control tissue morphogenesis. Finally, the talk will cover work on developing AI-powered bioprinting systems with enhanced precision and reproducibility.
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