Speaker
Description
A new approach in tissue engineering is the development of Cell- and Organ-on-a-chip systems. Thanks to the miniaturization, ensuring flow conditions and obtaining specific parameters such as large surface-to-volume (SAV) ratio and effective culture volume (ECV) it is possible to obtain culture conditions closer to in vivo. Microsystems have microstructures, in which different 3D culture models mimicking the function of tissue and organs are developed. Organ-on-a-Chip systems mimic in vivo microenvironment and enable to study response of the cells after the exposure to biophysical and biochemical and pathological factors. We developed 3D models of different tissue/organs such as lung, liver, heart, pancreas, brain, breast, vascular system which mimic organ function in Organ-on-a-Chip systems . These models have been based on the usage of hydrogels, self-organization, membranes, and scaffolds.
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