Speaker
Description
The LUMINATE consortium develops a personalized, one-stage regenerative approach to target large osteochondral lesions, thus preventing post-traumatic osteoarthritis and the associated patient burden. The LUMINATE consortium aims to develop an in situ bioprinting unit, called EndoFLight, which combines three pinting methods (filamented light, micro-extrusion, jetting) to print cartilage and bone photoresins laden with patient-derived cells directly at the site of injury. EndoFLight uses filamented light to bioprint highly architected scaffolds with excellent cell guidance properties. The LUMINATE approach represents a synergy between material development and characterization, custom printer software and hardware and engineering analyses of the mechanical and flow properties of the scaffolds. At the conclusion of the project, the clinical workflow will be validated through GMP processes and a in a large animal pre-clinical model. LUMINATE strives to develop in situ bioprinting therapies which will lessen patient suffering from osteochondral lesions and will pave the way for socioeconomic advantages for our aging society