Conveners
S02 3D complex architectures from stem cells
- Yifan Cui (ETH Zurich)
- Qi Gu (Beijing Institute for Stem Cell and Regenerative Medicine | Institute of Zoology, Chinese Academy of Sciences)
In every species of mammal, bird and reptile, and across almost the entire vertebrate world, the skin, lung, arteries and other tissues require elasticity to function. What bestows this elasticity is the protein elastin, which in turn is assembled from the structural protein building-block tropoelastin. We have found that tropoelastin can promote the repair many types of damaged tissues; and...
3D bioprinting has emerged as a transformative biotechnology in tissue and organ engineering. While substantial progress has been achieved in fabricating vascular networks with vessel diameters exceeding ~100 ฮผm - a scale primarily constrained by current bioprinting resolution - the engineering of functional microvasculature remains critical for enabling efficient mass transport within local...
Introduction: Cardiovascular disease remains the leading cause of mortality worldwide, with limited success in translating new therapies to the clinic. Existing in vitro modelsโsuch as 2D cultures and engineered heart tissuesโstruggle to recapitulate the complex cell-cell and cell-microenvironment interactions, as well as the structural and functional hallmarks of cardiac pathology within...
INTRODUCTION: Recent research on cancer therapy has increasingly focused on melatonin as a potential antitumor agent, particularly in liver cancer. Its mechanisms include modulation of apoptotic pathways, reduction of proinflammatory markers, and circadian rhythm regulation - all potentially relevant to inhibiting liver carcinogenesis. Alongside drug development, advancements in tissue models...
Introduction
Cardiovascular diseases, responsible for 17.9 million fatalities annually, are the leading cause of death worldwide. Congenital heart disease (CHD) is one of the causes of chronic CVD, which is the most common cause of congenital pathologies and the most common congenital malformation, affecting almost 1% of all live births. The standard treatment of CHD approach often involves...
Pancreatic islet transplantation holds significant potential for treating insulin-dependent diabetes, but its clinical utility remains limited by donor scarcity, immune rejection, and the need for lifelong immunosuppression. To overcome these challenges, stem cell-derived islets, particularly those differentiated from human induced pluripotent stem cells (iPSCs) engineered for...
Introduction. Mechano-transduction is the process by which cells sense and respond to mechanical stimuli from their environment, converting mechanical signals into biochemical signals that can influence cellular behavior, gene expression, and development [1]. In brain organoids, this mechanical cues are crucial for mimicking developmental processes, from embryonic development to neural stem...
