Conveners
S06 Advancing Biofabrication for Regenerative Medicine: From Innovation to Clinical Translation
- Axel Guenther (University of Toronto)
- Andreea Ioana Dinu (National University of Science and Technology Politehnica Bucharest)
Introduction
Surgical mesh implantation represents the current standard of care in inguinal hernia repair; however, conventional fixation using sutures is associated with risks of chronic neuralgia-type pain and local tissue irritation. Alternative fixation methods employing fibrin or cyanoacrylate-based adhesives have been introduced, but each presents inherent limitations in terms of...
Introduction
Osteoarthritis (OA) is a debilitating joint disease characterized by the progressive degradation of cartilage, leading to pain, stiffness, and limited mobility. Early detection and effective treatment are critical to improving patient outcomes. In this study, we introduce a combined method that uses a new way to deliver RNA with Silk Fibroin (SF) hydrogels and artificial...
Introduction:. An innovative approach combining pre-crosslinked methacrylated hyaluronic acid (HAPrime) with hybrid recombinant proteins was developed to create highly effective dressings for deep wound treatment. Treating deep wounds in animals, particularly pigs, remains a significant challenge due to risk of infection and delayed tissue regeneration. Emerging regenerative strategies, such...
Introduction: Tissue engineering has the potential to revolutionize the treatment of microtia, the congenital malformation of the external ear. Patient-specific auricular grafts could be engineered from a small biopsy of approximately 5 mg, eliminating the need for rib cartilage, and provide better aesthetics through biofabrication techniques, resulting in a real, natural ear. However, despite...
Introduction
Volumetric muscle loss due to trauma often exceeds the bodyโs intrinsic regenerative capacity. The gold standard of treatment with autologous transplants carries the significant drawbacks of donor site morbidity and limited availability. Although current tissue-engineered products offer potential, they require improvements in terms of shape fidelity, surgical handling, transport,...
Clinical application of beta-tricalcium phosphate (ฮฒ-TCP) has been limited by lack of bone infiltration within its bulk form. Lithography-based ceramic manufacturing (LCM), a novel additive manufacturing (AM) technique, leverages photopolymerization to create ฮฒ-TCP structures with higher feature resolution and surface quality than traditional techniques. This modality allows for a more...
Type 1 Diabetes Mellitus (T1DM) is an autoimmune condition resulting in the destruction of insulin-producing beta cells, leading to chronic hyperglycemia and accumulation of advanced glycation end products (AGEs). These factors contribute to serious complications such as diabetic foot ulcers (DFUs) (1-2), which result from chronic inflammation, vascular damage, and neuropathy. Despite their...
Introduction
The performance of hemodialysis membranes depends on uremic toxin clearance, biocompatibility, mechanical properties, and the ultrafiltration characteristics of the hemodialyzer [1]. The clearance rate can be controlled by membrane properties, such as thickness, morphology, and pore size, as well as the surface properties of the membrane [2].
Methods
Novel hemodialysis...
