2025 International Conference on Biofabrication

Session

S08b Biofabrication for cartilage regeneration and joint preservation

15 Sept 2025, 13:30

Ratuszowa

Conveners

S08b Biofabrication for cartilage regeneration and joint preservation

• Jos Malda (Utrecht University, NL)
• Francesca Diletta Spagnuolo (Trinity College Dublin)

554. IMPACT, a one-stage cell therapy for cartilage defects in the knee joint

Roel Custers (University Medical Center Utrecht)

15/09/2025, 13:30

invited lecture

Large cartilage defect of the knee joint can cause a major disabilty for young patients. At the UMC Utrecht, a one-stage cell therapy was developed, combining autologous chondrons with allogenieic mesenchymal stromal cells (IMPACT treatment). The IMPACT treatment is a perfect example of how a new brining a novel treatment from bench to bedside, a result of collaboration between...

260. TD-198946 Modulates Proliferation, Survival, and Chondrogenesis of iPSC-Derived NC-MSCs via NOTCH3 Pathway Activation

Anna Nakamura (Saga University)

15/09/2025, 13:50

podium presentation

Introduction:
Induced pluripotent stem cell (iPSC)-derived neural crest cells (NC-MSCs), following mesenchymal induction, exhibit strong chondrogenic potential, making them a promising source for cartilage repair. However, like other mesenchymal stem cells (MSCs), their potential decreases with repeated monolayer expansion. TD-198946, a small molecule, has been shown to enhance chondrogenic...

323. The stiffness of bone extracellular matrix derived scaffolds regulates osteogenesis of mesenchymal stromal cells

Giovanni Gonnella (Trinity College Dublin)

15/09/2025, 14:00

podium presentation

Bone extracellular matrix (ECM) shows considerable promise as a material for bone graft substitutes, primarily due to its intrinsic osteoinductive properties, which naturally support the process of bone formation. Bone ECM can be processed into highly porous scaffolds that facilitate effective cell infiltration and nutrient transport. A potential limitation of bone ECM scaffolds is their...

396. Post-Fabrication Development of Extracellular Matrix and Mechanical Properties in Cartilaginous Constructs Made from Hyaluronic Acid-based Bioinks

Paula Büttner (University Hospital Würzburg)

15/09/2025, 14:10

podium presentation

Introduction
Extrusion-based bioprinting represents a promising alternative to current cell-based approaches in cartilage regeneration. However, a major challenge in the fabrication of cartilage is still to achieve appropriate mechanical properties which are essential for biological functionality. In current biofabrication approaches bioinks are often combined with PCL scaffolds or other...

417. Borax-based Self-Healing Gels for Meniscus Tissue Engineering

Indra Apsite (University of Bayreuth)

15/09/2025, 14:20

podium presentation

Borax-based Self-Healing Gels for Meniscus Tissue Engineering
Selma. J. Padilla Padilla1, Pavel Milkin1, Indra Apsite1, Leonid Ionov1,2
1 Faculty of Engineering Sciences, University of Bayreuth, Ludwig Thoma Str. 36A, 95447 Bayreuth, Germany
2Bavarian Polymer Institute, University of Bayreuth, Bayreuth, Germany

The meniscus plays a crucial role in force transmission, shock absorption,...

326. In vivo evaluation of the long-term stability of printed osteochondral implants based on the reinforcement of soft hydrogels with non-degradable microfiber structures

Lennard Spauwen (UMC Utrecht)

15/09/2025, 14:30

podium presentation

Introduction
Osteochondral defects present a significant challenge due to the non-regenerative nature of articular cartilage (AC). Current treatments are limited in size, availability and durability.[1,2] Regenerative medicine and bioprinting offer a promising solution to overcome these challenges.[3] Soft hydrogels can be mechanically reinforced with microfiber box structures created with...

317. Personalized 3D multi-material printed scaffold for auricle reconstruction

Silvia Farè (Politecnico di Milano)

15/09/2025, 14:40

podium presentation

Introduction
Microtia and traumatic injuries are among the primary causes of external ear malformation or absence. Based on epidemiological data, approximately 1.46 out of every 10,000 newborns are affected by microtia, with 22.1% of these cases involving complete anotia [1]. To address these conditions, different ear reconstruction approaches have been developed, including autologous rib...

481. Nano-to-Microarchitectural Design: Intact Collagen Fibril Coatings on MEW Scaffolds to Enhance Chondrogenesis

Rory Gibney (Trinity College Dublin)

15/09/2025, 14:50

podium presentation

Introduction
Melt electrowriting (MEW) is an additive manufacturing technique with significant potential in cartilage tissue engineering. While osteoinductive coatings have been employed to functionalize MEW scaffolds, the efficacy of comparable chondro-inductive coatings remains unproven. Type II collagen and sGAGs are key cartilage ECM components that promote chondrogenesis when included in...