Conveners
S08b Biofabrication for cartilage regeneration and joint preservation
- Jos Malda (Utrecht University, NL)
- Francesca Diletta Spagnuolo (Trinity College Dublin)
Large cartilage defect of the knee joint can cause a major disabilty for young patients. At the UMC Utrecht, a one-stage cell therapy was developed, combining autologous chondrons with allogenieic mesenchymal stromal cells (IMPACT treatment). The IMPACT treatment is a perfect example of how a new brining a novel treatment from bench to bedside, a result of collaboration between...
Introduction:
Induced pluripotent stem cell (iPSC)-derived neural crest cells (NC-MSCs), following mesenchymal induction, exhibit strong chondrogenic potential, making them a promising source for cartilage repair. However, like other mesenchymal stem cells (MSCs), their potential decreases with repeated monolayer expansion. TD-198946, a small molecule, has been shown to enhance chondrogenic...
Bone extracellular matrix (ECM) shows considerable promise as a material for bone graft substitutes, primarily due to its intrinsic osteoinductive properties, which naturally support the process of bone formation. Bone ECM can be processed into highly porous scaffolds that facilitate effective cell infiltration and nutrient transport. A potential limitation of bone ECM scaffolds is their...
Introduction
Extrusion-based bioprinting represents a promising alternative to current cell-based approaches in cartilage regeneration. However, a major challenge in the fabrication of cartilage is still to achieve appropriate mechanical properties which are essential for biological functionality. In current biofabrication approaches bioinks are often combined with PCL scaffolds or other...
Borax-based Self-Healing Gels for Meniscus Tissue Engineering
Selma. J. Padilla Padilla1, Pavel Milkin1, Indra Apsite1, Leonid Ionov1,2
1 Faculty of Engineering Sciences, University of Bayreuth, Ludwig Thoma Str. 36A, 95447 Bayreuth, Germany
2Bavarian Polymer Institute, University of Bayreuth, Bayreuth, Germany
The meniscus plays a crucial role in force transmission, shock absorption,...
Introduction
Osteochondral defects present a significant challenge due to the non-regenerative nature of articular cartilage (AC). Current treatments are limited in size, availability and durability.[1,2] Regenerative medicine and bioprinting offer a promising solution to overcome these challenges.[3] Soft hydrogels can be mechanically reinforced with microfiber box structures created with...
Introduction
Microtia and traumatic injuries are among the primary causes of external ear malformation or absence. Based on epidemiological data, approximately 1.46 out of every 10,000 newborns are affected by microtia, with 22.1% of these cases involving complete anotia [1]. To address these conditions, different ear reconstruction approaches have been developed, including autologous rib...
Introduction
Melt electrowriting (MEW) is an additive manufacturing technique with significant potential in cartilage tissue engineering. While osteoinductive coatings have been employed to functionalize MEW scaffolds, the efficacy of comparable chondro-inductive coatings remains unproven. Type II collagen and sGAGs are key cartilage ECM components that promote chondrogenesis when included in...
