Conveners
S11a Biofabrication of Soft Tissues
- Efsun ลentรผrk (La Sapienza)
- Vijayavenkataraman Sanjairaj (New York University Abu Dhabi)
Gingival recession, a prevalent condition affecting the gum tissues, is characterized by the exposure of tooth root surfaces due to the displacement of the gingival margin. This presentation will emphasize the critical considerations in gingival tissue engineering leveraging on cells, biomaterials, and signaling factors. Successful tissue-engineered gingival constructs hinge on strategic...
Adipose tissue is a crucial organ involved in energy metabolism, endocrine signaling, and immune regulation, making it a key target for regenerative medicine, disease modeling, and cultured meat applications. While traditional tissue engineering approaches have made significant progress in adipose tissue reconstruction, the biofabrication of functional and physiologically relevant adipose...
The intricate architecture of the human central nervous system (CNS) presents significant challenges in neuroscience in developing in vitro models that accurately replicate its structure and function under both physiological and pathological conditions. The brainโs highly organized and layered regions, each characterized by distinct cellular phenotypes and extracellular matrix (ECM)...
Introduction
Diabetes is a chronic, globally prevalent disease characterized by impaired pancreatic islet cell function. Existing treatments, such as pancreatic islet transplants or exogenous insulin, do not fully restore physiological pancreatic function. This has prompted the search for alternative therapies. Implementing 3D bioprinting of functional pancreatic organoids that mimic native...
The extracellular matrix (ECM) of the central nervous system is a specialized, ultra-soft structure that provides crucial biochemical and mechanical support for neuronal survival, differentiation, and synaptic connectivity. It consists of a network of biomolecules, including glycosaminoglycans like hyaluronic acid, as well as structural and adhesive proteins such as laminins. Laminins play a...
Introduction
Duchenne muscular dystrophy (DMD) results from mutations in the DMD gene, leading to the absence of dystrophin protein and fatal skeletal muscle wasting. Currently, no approved treatments address DMDโs root cause. An in vitro skeletal muscle model would provide a platform to study cause and develop therapeutic strategies. However, existent models fail to recapitulate the genetic...
INTRODUCTION
Although a complete understanding of the mechanisms by which ECM stiffness impacts cellular development has not been fully achieved, the biomechanical properties of ECM have been shown to play a significant role in regulating cell proliferation (Mih et al. 2012), migration (Ehrbar et al. 2011), and differentiation (Han et al. 2020) among other phenomena. Furthermore, the...
