Conveners
S15 Bioprinting approaches in the EU projects
- Ayça Bal Öztürk (Istinye University and ADBioink, Turkey)
- Giovanni Vozzi (University of Pisa, Italy)
The LUMINATE consortium develops a personalized, one-stage regenerative approach to target large osteochondral lesions, thus preventing post-traumatic osteoarthritis and the associated patient burden. The LUMINATE consortium aims to develop an in situ bioprinting unit, called EndoFLight, which combines three pinting methods (filamented light, micro-extrusion, jetting) to print cartilage and...
A fundamental limitation with current approaches aiming to bioprint tissues and organs is an inability to generate constructs with truly biomimetic composition and structure, resulting in the development of engineered tissues that cannot execute their specific function in vivo. This is perhaps unsurprising, as many tissues and organs continue to mature postnatally, often taking many years to...
Colorectal diseases are a cohort of pathologies that affect the mucosa and submucosa layers of the anus, rectum, and colon of more than 2 million individuals in the European Union [1]. Among them, familiar adenomatous polyposis (FAP) and ulcerative colitis (UC) seriously compromise the patients’ quality of life. These pathologies could benefit from the removal of the intestinal mucosa and...
Introduction
Hydrogels are three-dimensional networks of polymers that can absorb and store large amounts of water. Conventional hydrogels are based on static covalent crosslinks, which limits their adaptability to varying mechanical loads and environmental conditions. In supramolecular hydrogels the chains in the network are connected by reversible physical bonds that confer viscoelastic...
Traumatic injuries to the osteochondral tissues of diarthrodial joints like the knee result in pain, functional impairment, and increased risk of developing post-traumatic osteoarthritis (PTOA) and its comorbidities. Strikingly, up to 50% of patients suffering from severe trauma to the knee joint develop PTOA within 10 years from the injury. Current treatments, based on allografts, cell-free...
Organ transplantation remains the only curative treatment for patients with end-stage liver disease, yet the chronic shortage of donor organs leaves thousands of patients without timely access to life-saving therapies. Approximately 25% of patients on the liver transplant waiting list either die or deteriorate beyond eligibility. To address this critical gap, the NEOLIVER project aims to...
Background
Biofabrication technologies are advancing rapidly, offering novel therapeutic strategies for regenerating complex tissue defects. The LUMINATE project, co-funded under the Horizon Europe programme, focuses on the development of an AI-powered bioprinter for intraoperative repair of osteochondral tissue. The device combines high-precision material deposition and AI-powered process...
Colorectal diseases refer to a range of conditions that affect the mucosal and submucosal layers of the anus, rectum, and colon, impacting over 2 million individuals across the European Union [1]. Among these, familial adenomatous polyposis (FAP) and ulcerative colitis (UC) significantly reduce the quality of life of affected patients. While these conditions might benefit from removing the...
