Conveners
S20 Emerging Bioprinting Platforms for Musculoskeletal Tissue Engineering
- Francesca Diletta Spagnuolo (Trinity College Dublin)
- Eben Alsberg (University of Illinois Chicago)
Lesions in the menisci are frequently related to sports injuries and dramatically increase the risk of developing osteoarthritis. It is estimated that 1.5 million meniscal repairs are performed annually in the United States and Europe, representing one of the most common clinical procedures performed by orthopaedic surgeons. In the field of tissue engineering there is increased interest in the...
Our musculoskeletal system has a limited capacity for repair. This has led to increased interest in the development of tissue engineering and biofabrication strategies for the regeneration of musculoskeletal tissues such as bone, ligament, tendon, meniscus and articular cartilage. This invited talk will demonstrate how different musculoskeletal tissues, specifically cartilage, bone and...
Articular cartilage (AC) transmits large mechanical loads in synovial joints. This tissue’s properties derive from its unique composition and structure, which consists of glycosaminoglycans and type II collagen arranged into arcade-like structures [1]. AC has a limited capacity for regeneration, hence damage here typically leads to the development of osteoarthritis, a disease impacting the...
Introduction: Three dimensional (3D) bioprinting provides a wide avenue to design complex and customized constructs for tissue regeneration, disease modelling, and drug testing applications. Bioink formulations in 3D bioprinting usually lack the presence of micrometre-sized and interconnected pores, resulting in reduce cell viability and prevent biological communications with host tissues,...
Abstract
Introduction
Osteosarcoma (OS), the most common malignant bone tumor, poses significant clinical challenges due to its aggressive progression and limited therapeutic options for metastatic disease[1]. Current preclinical models fail to replicate the mechanical and biochemical complexity of the bone microenvironment[2]. This study explores melt electrowriting (MEW) technology to...
The myotendinous junction (MTJ) is a highly specialized interface that connects skeletal muscle to tendon, enabling the transmission of contractile forces and ensuring efficient biomechanical performance of the musculoskeletal system. Functionally, the MTJ plays a pivotal role in maintaining structural continuity between two developmentally distinct tissues—muscle and tendon—while withstanding...
Abstract
Skeletal muscle plays a critical role in voluntary movement and metabolic regulation, and its dysfunction is implicated in the onset and progression of musculoskeletal and systemic diseases. While interest in the development of therapeutics for skeletal muscle disorders is steadily increasing, conventional in vitro models are limited by low throughput, the complexity of platform...
