Conveners
S21 From Bulk to Micro-Architecture: Hydrogel Engineering and Bio-Fabrication for Skeletal Tissue Applications
- Ayse Kose (KU Leuven)
- Andreas Dimopoulos (KU Leuven)
Biofabrication technologies, including extrusion bioprinting, bioassembly, digital light processing (DLP) and volumetric bioprinting (VBP), offer the potential to engineer constructs consisting of cell-laden bioinks, tissue modules, and/or bioactive factors that replicate the complex 3D organization of native tissues. Despite rapid advances however, development of individual bioinks for each...
Approaches towards tendon microarchitecture through melt electrowriting and melt-electrofibrillation
Jรผrgen Groll
Department of Functional Materials in Medicine and Dentistry at the Institute for Functional Materials and Biofabrication & Bavarian Polymer Institute, University of Wรผrzburg, 97070 Wรผrzburg, Germany
Melt electrowriting (MEW) is a relatively young additive manufacturing...
Fibrin-based biomaterials are clinically established for their biocompatibility, resorbability, and hemostatic function, and have found widespread use in surgical sealants and wound repair [1]. However, their application in bone regeneration remains limited due to intrinsic softness, fast degradation, and poor mechanical tunability [2]. To address these shortcomings, we present a novel,...
Introduction
Volumetric muscle loss (VML) is a traumatic or surgical injury of the skeletal muscles with irrecoverable functions, which leads to chronic deficits and long-term disability. Regenerative medicine using mesenchymal stem cells (MSCs) is a potent therapeutic approach for VML due to their tissue regenerative ability. However, the therapy for VML remains a challenge in regenerative...
Bulk hydrogels are comprised of nanoporous polymer networks, and thus restrict cell motility, cell-cell interactions, and nutrient diffusion in bioengineered tissues. To overcome these challenges, interest has shifted toward the fabrication of interconnected microporous hydrogels, which improve nutrient transport, facilitate cell migration, and promote tissue ingrowth. Current fabrication...
Polylactic acid (PLA) is an eco-friendly and biocompatible polymer commonly utilised in bone tissue engineering. However, its absence of antibacterial properties and susceptibility to wet chemical processes hinder its clinical application. Atmospheric pressure plasma (APP) is widely used for surface activation, but its application is typically confined to shallow surface modifications due to...
The regeneration of skeletal muscle (SM) tissue and its interfacesโnamely the myotendinous junction (MTJ) and neuromuscular junction (NMJ)โremains a significant challenge in both engineering and clinical domains. Recent advances in biofabrication have begun to address these hurdles, enabling the creation of biomimetic architectures with precise spatial control over cellular organization and...
