Conveners
S22a Microfluidics and Biofabrication for Next-Generation bioengineering
- Ozlem Yesil-Celiktas (Ege University)
- Fabio Maiullar (Institute of Physical Chemistry, Polish Academy of Sciences)
The modular design of tissues is of indispensable importance for proper organ function. Yet, most tissue engineering strategies are based on creating homogeneous tissues, which has limited are capacity to create viable and functional tissues. I will discuss several novel micromaterials and biofabrication strategies we developed to create engineered living matter with modular designs that allow...
Introduction
The research concept is based on the [2+2] cycloaddition reaction of double bonds embedded in the modified polymer structure, enabling efficient and initiator-free hydrogel crosslinking upon light exposure. It is widely recognized that degradation by-products of photoinitiators exhibit cytotoxicity, which is a major limitation in the field of biomaterials engineering. To overcome...
Abstract:
Background:
The development of physiologically relevant tumor models is critical for understanding the tumor microenvironment (TME) and its influence on therapeutic response. In breast cancer, cancer-associated fibroblasts (CAFs) are key stromal players that remodel the extracellular matrix (ECM), promote tumor progression, and confer drug resistance. However, conventional static...
Human bone exhibits exceptional mechanical properties due to its hierarchical architecture, which span from the nano/microscopic to the macroscopic scale. The increasing incidence of orthopaedic disorders, as fractures, osteoporosis-related bone loss, and joint degeneration is a growing concern, especially among the aging population. This trend has increased the demand for effective bone graft...
Introduction. The liver is a key organ that plays a crucial role in metabolism and is responsible for various functions in the body, including homeostasis, synthesis of essential components, nutrient storage, and detoxification [1]. With the growing need for reliable and effective in vitro liver models for toxicological studies, recent advances have been made in tissue engineering,...
Spermatogenesis is a highly coordinated process occurring within the seminiferous tubules, where germ cells develop in close association with somatic Sertoli cells (SCs). These cells provide essential structural, metabolic, and regulatory support to developing germ cells, and their functionality is tightly regulated by the surrounding extracellular matrix (ECM). However, replicating the...
Introduction
Shape changes during heart development, known as looping, are crucial for its morphogenesis [1]. Conventional bioprinting techniques produce static structures that bypass the shape-morphing cascades, essential for tissue maturation during development. 4D materials that can undergo shape changes due to external stimuli such as magnetic fields, light, etc., can play a key...
Introduction:
Accurate preclinical drug evaluation relies on physiologically relevant models that replicate the native tissue microenvironment, including structural architecture and vasculature. Liver cancer, a major global health burden, often requires complex and individualized treatment strategies. However, current therapeutic approaches are typically generalized, failing to address...
