Conveners
S24 ISBF-ESB: How biomaterials design can help bioprinting?
- Debby Gawlitta (UMC Utrecht)
- Gianluca Ciardelli (Politecnico di Torino)
Introduction
Chronic Lymphocytic Leukemia (CLL) is the most common hematological malignancy in the Western World [1], caused by the expansion and accumulation of B lymphocytes in peripheral blood, bone marrow, lymph nodes and spleen. To date, the comprehension of the interactions between CLL cells and the tumor microenvironment (TME) is challenging to implement novel therapiesIn this study,...
In the quest to capture the complex environment of living organs within lab-made tissues, light emerged as a uniquely powerful stimulus for enabling dynamic and spatio-temporal control over cell and biomaterial properties, opening new avenues in regenerative medicine and tissue engineering. Light-responsive moieties permit to non-invasively trigger mechanical actuation and shape-changes in...
Introduction
For 3D bioprinted structures to function effectively as tissues, it is essential to promote the proliferation of encapsulated cells. At the same time, it is important to be able to print with high structural fidelity to the blueprints designed to perform biological functions. Different techniques are currently used to meet each of these requirements. Cell proliferation is...
Introduction
Volumetric additive manufacturing (VAM) is emerging as a powerful biofabrication approach, allowing the rapid generation of complex, cell-laden hydrogel scaffolds. Unlike traditional layer-by-layer 3D printing, VAM enables high-speed fabrication, offering significant advantages for tissue engineering (TE).[1] Hydrogels derived from gelatin-based polymers, particularly those...
Introduction: Biological tissues exhibit intricate spatial variations, stiffness gradients, and complex niche environments critical to their biological function and implicated in various pathologies. Organ-on-chip technologies offer advanced biomimetic culture conditions compared to traditional culture methods[1-2]. However, replicating native tissue complexity remains challenging, requiring...
We have been proposing the use of human-derived proteins that, upon chemical modification, could be used to generate adequate microenvironments to interact adequately with cells. We have selected two sources of such materials: (i) platelet lysates, containing mostly globular proteins including relevant growth factors with highly regenerative potential; and (ii) proteins from amniotic membrane...
Introduction:
Despite major advances in tissue engineering one key challenge remains: to ensure cell survival inside large, engineered constructs. Diffusion alone cannot sustain cell viability to the construct core, making it critical to develop strategies that support cells until a functional vascular network forms, regardless of construct size. Recent approaches to address this issue...
