Conveners
S27 Medical Biotechnology
- ลukasz Matusiak (Warsaw University of Technology)
- Jakub D. Rybka (Adam Mickiewicz Univeristy)
How can we durably regenerate damaged tissues in the human body? Despite major advances in regenerative medicine, this fundamental question remains largely unanswered. Current cell-based tissue engineering strategies allow us to create living implants in the laboratory, and through biofabrication we can design constructs that resemble native tissues in composition and morphology. However,...
In the human body, tubular structures are prevalent and exhibit various architectures, such as those found in the vascular and lymphatic systems. For instance, blood vessels can be viewed as tubular constructs with a specific diameter when considering their macroscopic shape. A closer examination reveals that these vessels consist of multiple layers, each composed of different extracellular...
Introduction: Bone tissue engineering (TE) aims to develop biomaterials that replicate the specific mechanical strength essential for the functional characteristics of the bone (1). Osteoblastic spheroids provide a three-dimensional (3D) culture model that better mimics in vivo conditions than traditional two-dimensional (2D) cultures. Amorphous calcium phosphate (ACP), derived from eggshell...
Despite advances in surgical reconstruction of the head and neck region in recent years, several clinical scenarios continue to pose significant reconstructive challenges such as the reconstruction of complex maxillofacial defects affected by chemotherapy, and/or radiation. The common factor which makes these typically post-traumatic or post oncologic defects difficult to treat is the...
Cell microencapsulation is a widely studied strategy for immunoprotection of transplanted insulin-producing cells used for diabetes treatment. The microcapsule forms a semipermeable membrane around the transplanted cells, serving as a barrier protecting cells from the host immune system while allowing diffusion of nutrients, glucose, and insulin.
The most widely studied microencapsulation...
Introduction
Organoids are miniaturized three-dimensional layered constructs offering unprecedent resemblance with the structural, biological and functional characteristics of organs. These models provide a new framework to study the cellular processes, the physiology and the treatment of pathologies at the organ-level. Beyond in vitro modelling, organoids can offer a new alternative for in...
The development of three-dimensional (3D) cell-only tubular tissue constructs at small lumen sizes is a significant challenge in tissue engineering. This study presents an innovative strategy for fabricating multi-layered living conduits with defined geometries by 3D bioprinting multiple cell-only bioinks along with an oxidized and methacrylated alginate (OMA) microgel ink into a supporting...
3D biological models able to reproduce the physiology and the behavior of human tissues/organs are the focus of the newest groundbreaking research, enabling the scientific advancement of personalized medicine while simultaneously adhering to the principle of the 3Rs. Among the key features necessary to achieve a physiological and functional 3D model, there is the ability to replicate an immune...
