Conveners
S28 Multicellular 3D models of neuronal diseases in various bioinks: Hypes and falls
- Natascha Schรคfer (Institute for Clinical Neurobiology, University Hospital Wรผrzburg, Germany)
- Efsun ลentรผrk (La Sapienza)
The human nervous system is one of the most complex to model in vitro. It encompasses the largest diversity of cell types, with the most intricate โhub-and-spokeโ networks. Advancements in stem cell biology have enabled development of more sophisticated 3D models of the โhubโ, i.e. central nervous system, with the emergence of organoids and assembloids. However, 3D models of the โspokeโ...
During brain morphogenesis, neurons extend axons over large distances along well-defined pathways. Axon pathfinding is regulated by both chemical and mechanical signals. However, we currently know very little about how these signals interact. We here show how local mechanical brain tissue properties contribute to guiding neuronal axons. In vivo time-lapse atomic force microscopy revealed...
Introduction
A deeper insight into the tumor microenvironment (TME) is crucial for advancing cancer research. In order to study the TME in depth, 3D cell culture models are preferred over traditional 2D cultures, as they offer a more accurate representation of cellular behaviour and functional aspects, when interacting with an extracellular matrix (ECM) like structure. This includes key...
Introduction
External forces, notably in traumatic brain injury, can cause tissue-level damage [1, 2]. Meanwhile, mechanical cues on a smaller scale are pivotal in shaping the development, behavior, and function of individual neural cells [3]. Advancing our understanding of injury and disease mechanisms in the central nervous system depends on investigating how cellular forces and tissue...
Glioblastoma multiforme (GBM), the most aggressive brain tumor, interacts with its tumor microenvironment (TME) through complex mechanisms. GBM-TME interactions are primary drivers of tumor malignancy and progression. The TME consists of the extracellular matrix (ECM) and various cells of the brain. Novel research strategies to expand on the understanding of these interactions as a...
Introduction: The translation of signals between the human body and biomedical implants is a critical challenge in advancing tissue engineering, regenerative medicine, and diagnostics. Minimizing the inherent differences between neural biological components and synthetic interfaces, particularly in stiffness, biocompatibility, and cellular cues, is crucial for effective neural interfaces1. In...
Introduction
The infections, exogenous chemicals, such as drugs1, environmental pollutants and industrial chemicals, may affect the biological processes of the central nervous system as well as its structural, cellular, and molecular function2 and eventually lead to neuroinflammation3 as well as neurotoxicity4. Neuroinflammation is the common cause of numerous neurological disorders,...
