Conveners
S29 New approaches in tissue engineering
- Aida Fadakarsarkandi (The University of Birmingham)
- Jan Guzowski (Institute of Physical Chemistry PAN)
A new approach in tissue engineering is the development of Cell- and Organ-on-a-chip systems. Thanks to the miniaturization, ensuring flow conditions and obtaining specific parameters such as large surface-to-volume (SAV) ratio and effective culture volume (ECV) it is possible to obtain culture conditions closer to in vivo. Microsystems have microstructures, in which different 3D culture...
Introduction: The production of acetylcholine (ACh), a neurotransmitter regulating cardiac function, is significantly reduced following myocardial damage in vivo. Previous studies demonstrated that ACh administration can be used to reduce infarct size following myocardial infarction (MI) and ischemic-reperfusion (I/R) injury in in vivo animal models. This has been associated with ACh-mediated...
The basement membrane (BM) is a crucial extracellular matrix that provides structural support, regulates cell adhesion and migration, and influences cell behavior in various organs. Composed of proteins like collagen and laminin, it plays essential roles in tissue development, repair, and homeostasis. Disruptions in the BM are linked to diseases such as cancer and fibrosis. However, its...
Introduction The kidney glomerulus acts as the blood-filtering unit in the kidney and plays a crucial role in maintaining homeostasis. The glomerular filtration barrier is a size-selective filter composed of endothelial cells and podocytes, separated by the glomerular basement membrane. Dysfunction of the barrier can result in proteinuria, often followed by progressive renal damage and kidney...
The major challenges in new drug development are the low translational efficiency (<10%), soaring costs (>$5 billion/drug) and ethical concerns regarding animal welfare. The emergence of a novel research field with bioengineering promises to offer new strategies to create non-animal models using human cell lines to address these shortcomings. Absence of vascularisation is one of the main...
Background
Access to healthy living tissue in the lab has always been an essential substrate for experimentation across the breadth of medical research. Historically limited to live animal studies using small mammals such as rats, and subsequently more anatomically and physiologically analogous animals such as pigs, recent developments in cellular technologies have allowed for the in-vitro...
Objectives: Volumetric bioprinting (VBP) technologies have demonstrated unparalleled potential for printing centimeter-sized engineered tissues, with intricate architectures, in minutes. However, they still face limitations in scalability and resolution. Recently, a next-generation volumetric 3D printing technique named Xolography was introduced. Xolography operates by intersecting a UV-light...
