Conveners
S30 New Dimensions in Biofabrication: Emerging tools and perspectives
- Jos Malda (Utrecht University)
- Gosia Wlodarczyk-Biegun (University of Groningen / Silesian University of Technology)
Bioprinting is facing several scientific and technological challenges toward having a clear clinical impact. Together with the complexity of multimaterial and multiscale features required for the fabrication of functional and effective bioprinted constructs, it is necessary to consider the compelling request of a consistent high quality, including inter-batch variability, and safety (e.g.,...
Quantum sensing for assessing the interaction between materials and cells
Daniel Wojtas, Aldona Mzyk, Alina Sigaeva, Yue Zhang, Yuchen Tian, Romana Schirhagl
University Medical Center Groningen
New biomaterials are developed for many applications including drug delivery, tissue engineering implants. All these materials interact with the human body and with cells and it is crucial to...
Self-assembling scaffolds enable enhanced adaptation to the human body environment thanks to a dynamic response to external stimuli. To produce such scaffolds, advanced biofabrication methods are required. Melt electrowriting (MEW) is a high-precision additive manufacturing technique, which enables the creation of fine fibers of molten polymer under the influence of an electrical field....
Introduction
Three-dimensional (3D) microtissue spheroids replicate native-like microenvironments and thus provide a model platform to study cell-matrix dynamics. Furthermore, modular bioassembly of these cell-dense units allows for precise control over 3D tissue architecture, while maintaining physiological cellular microenvironments. However, successful biofabrication of large-scale tissues...
Introduction: Tissue function depends on the intricate 3D organization of cells, matrix components, bioactive cues, and dynamic factors like nutrient and oxygen gradients, and mechanical forces. Advances in bioprinting have enhanced cellular organization, yet full tissue maturation, critical for biological function, often requires post fabrication measures. Here, we introduce a novel method to...
Introduction
We have already shown that the Acoustic Droplet Ejection (ADE) technology facilitates the precise, nozzle-less transfer of cell-laden bioinks [1]. This technique offers an alternative to traditional bioprinting methods like microextrusion or inkjet, circumventing nozzle-related issues such as clogging and high wall shear stress. By eliminating the nozzle, ADE significantly...
Introduction
3D in-vitro models offer a more accurate simulation of in-vivo conditions than traditional 2D cell cultures. Vascularization is currently a hot topic in tissue modeling, helping to mimic the in-vivo environment, adding physiological relevance, and aiding the supply of nutrient and oxygen as the removal of metabolic waste1. Also, perfused vascular networks allow better biomimicry...
