Conveners
S33 Redefining Cancer Modeling: Patient-Derived Organoids Enabled by Extracellular Matrix (ECM)-Inspired Scaffolds
- Dรฉsirรฉe Baruffaldi (Department of Applied Science and Technology, PolitoBIOMed Lab, Politecnico di Torino)
- Andrea Cosola (Department of Applied Science and Technology, PolitoBIOMed Lab, Politecnico di Torino)
Biliary complications, such as post-operative biliary strictures, pose serious health risks and place a significant burden on healthcare systems. Conventional treatments, including plastic stents, require frequent replacement, while self-expanding metal stents, despite longer patency, carry risks such as migration and tissue ingrowth. Biodegradable scaffolds offer a promising alternative due...
In the last twenty years, the systemic cytotoxic chemotherapy approach left gradually place to a more personalized clinical concept, aiming to identify and target tumor peculiarities which make one tumor different from another. The lack of coherence between experimental results and in vivo effectiveness confirmed the limitation of using clonal 2D cell cultures to predict the efficacy of...
Introduction
Ovarian cancer (OC) is the leading cause of death among gynecological malignancies, primarily due to its high mortality rate and frequent recurrence. The standard treatment, platinum-based chemotherapy, often becomes ineffective as patients develop platinum resistance, a process associated with enhanced metastatic potential, epithelial-mesenchymal transition (EMT), and...
Transforming Pre-Clinical Drug Testing: 3D Bioprinted Patient-Derived Breast Cancer Models on a Microfluidic Device
Pragati Sharma1 and Subha Narayan Rath1
1Regenerative Medicine and Stem Cell Laboratory (RMS), Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Sangareddy 502284, Telangana, India.
Correspondence: Subha Narayan Rath, Email:...
Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Nanomedicine has shown significant potential in enhancing treatment outcomes and in overcoming the limitation of traditional therapeutic approaches. However, a major challenge lies in translating these advancements into clinical applications. To bridge this gap, we propose a 3D bioprinted model that mimics CRC...
The available methods of reproducible formulation of human tumor microenvironments (hTMEs) that is micro-engineered systems incorporating cancer, stroma and extracellular matrix (ECM), that could serve as preclinical models of disease, e.g., in anti-cancer drug testing, currently suffer from excessive complexity (organ-on-chip systems) and/or low-throughput (3D bioprinted constructs). Here, we...
Glioblastoma (GBM) is a highly invasive and heterogeneous brain tumor, making it particularly difficult to replicate its complex tumor microenvironment (TME) in vitro. One promising approach involves using GBM-derived decellularized extracellular matrices (dECMs), which closely mimic the native TME. These dECMs contain tumor-specific biochemical components such as glioma-associated...
