Conveners
S34 Smart Materials in Biofabrication
- Giovanni Gonnella (Trinity college Dublin)
- Hossein Ravanbakhsh (University of Akron)
Smart Materials, broadly defined here as any biomaterial that alters its shape and material properties over a time period ranging from minutes to years in response to externally applied (light, heat, etc) or host (fluid, cells, etc.) stimuli hold tremendous promise for fabricating resorbable, implanted devices for pediatric reconstruction applications. Regulatory approval requires...
Burn injuries and related wound infections are the leading cause for >150.000 deaths worldwide each year. Skin defects caused by burns or infection may necessitate grafting to augment wound healing. As early identification of relevant contaminants is essential to adequately treat wound/graft infection as a potential life-threatening complication, real-time monitoring of bacterial overgrowth...
Introduction: Ulcers are a breach in the membrane of the stomach or intestine caused by inflamed necrotic tissue. When they develop in the ileum and jejunum, ulcers represent a burden clinical challenge, since they are not accessible through colon- or gastroscopy[1]. To solve this clinical need, in the context of the PRIN2022 project Prometheus, we studied the fabrication of a multi-layered...
Introduction
3D printing of hydrogels usually relies on a combination of fine-tuned material chemistry and polymer chain architecture to produce inks with adequate viscoelastic properties such as yield-stress flow, shear-thinning and self-healing behavior. [1] Complex coacervates are versatile materials obtained through an associative liquid-liquid phase separation phenomenon driven by...
Introduction
Embedded bioprinting enables the deposition of bioinks within a supportive matrix, traditionally composed of viscoplastic gels. While these materials offer mechanical stability, they often compromise nutrient and oxygen transport to embedded cells [1]. To address these limitations, our group introduced in-foam bioprinting, a novel approach that utilizes a nutrient-rich,...
Introduction
To advance 3D bioprinting, it is essential to develop bioinks with appropriate rheological (e.g., flow behavior, yield stress) and gelation (e.g., kinetics, storage modulus) properties to enhance printability. Previous studies have incorporated additional components into bioinks, such as rheology modifiers (e.g., nanofibers, nanoparticles) and secondary crosslinking...
Introduction: Hydrogel electronics have emerged as promising alternatives to traditional rigid metallic electronics for bioelectronic and human-machine interfaces, owing to their intrinsic biocompatibility and physicochemical similarities to biological tissues1. Despite their promise, most conductive hydrogel systems rely on metallic fillers or nanomaterials to achieve sufficient conductivity,...
Shape memory polymers (SMPs) are a class of smart materials capable of undergoing programmed shape changes in response to external stimuli. Polyglycerol dodecanoate acrylate (PGDA), a thermally responsive SMP, has demonstrated promise in biomedical applications due to its biocompatibility.[1] However, its high viscosity and the requirement for harsh thermal curing hinder its use in vat-based...
