Conveners
S35 Stretching the Frontiers: Advanced Applications of Biofabricated Skeletal Muscle
- Nehar Celikkin (IPC PAS)
- Sahar Salehi-Müller (University of Bayreuth)
The skeletal muscle tissue exhibits good regenerative capabilities, which are however limited by injury size. As a matter of fact, large muscle lesions are characterized by poor recovery accompanied by scar formation and functional detriment, condition common to people suffering from volumetric muscle loss and needing reconstructive therapeutic approaches. Even if surgical autologous...
Volumetric muscle loss (VML) refers to muscle tissue loss exceeding 20% within a functional area due to trauma or surgery, often leading to physical disabilities. VML treatment relies on the transplantation of autologous flaps harvested from a healthy-donor site while minimizing the probability of immune rejection. However, this approach often leads to donor-site morbidity and relies on a...
Introduction. Achieving physiologically relevant maturation of engineered skeletal muscle in vitro remains a major challenge in tissue engineering (1, 2). Traditional stimulation approaches often fail to recapitulate the spatiotemporal precision of native neuromuscular activation (3, 4). In this context, light-responsive molecular transducers represent a promising tool to drive muscle...
Introduction: Ionic medicine is an approach that proposes the use of therapeutic ions to stimulate cell growth, reduce inflammation, combat oxidative stress, and promote tissue regeneration1. Biofabrication offers a solution for addressing muscle loss in situations where the human body cannot heal itself effectively2. To enhance muscle cell growth by ionic stimulation, this study established a...
Synthetic muscles that replicate the distinct contraction and force-generating properties of native skeletal muscle are highly sought after. They are used in a variety of applications, including actuators and regenerative therapies such as muscle replacement. Two-photon stereolithography is a promising tool to fabricate bio-scaffolds with micrometer resolution, ideally replicating soft native...
Introduction:
Biofabrication in space enables the production of patient-specific, structurally complex tissue constructs with customized properties (e.g., cell density, material composition, architecture), essential for future long-duration missions. Although substantial progress has been made in evaluating biofabrication strategies for space applications, the fabrication of anisotropic,...
Introduction
Skeletal muscle is a highly organized and heterogeneous tissue composed of multiple cell types and structural components, arranged in a complex hierarchical architecture. This structure is essential for its mechanical strength, contractile function, and ability to regenerate. Skeletal muscles possess a strong capacity for self-repair; however, they are unable to regenerate...
