Conveners
S37 Celebrating 25 years of gel-MA: The importance of standardization in gelatin materials towards clinical translation
- Jos Olijve (Rousselot Biomedical)
- Jasper Van Hoorick (BIO INX BV)
Photoresponsive gelatin derivatives are among the most used biomaterials to produce bioink and bioresins for biofabrication. The unique thermoreversible gelation properties of gelatin, combined with covalent crosslinking strategies via the incorporation of i.e. acrylates groups offers a broad range of rheological performances suitable for both extrusion and light-based printing applications....
Hydrogels with tailored porosity and microstructure are essential for biomedical applications such as drug delivery and tissue engineering. However, controlling their internal architecture remains a challenge. A promising approach leverages polymer phase separation in water to create hydrogels with large interconnected pores, enhancing cell growth or migration, nutrient transport, and cellular...
Introduction
Cholangiocarcinoma (CCA) is a rare but deadly disease that arises from epithelial cells in the liver (intrahepatic) or the biliary tract (extrahepatic). The absence of specific symptoms leads to late diagnosis, which is associated with a poor prognosis due to disease progression, metastasis, and the emergence of drug resistance. The heterogeneity of CCA makes the drug discovery...
Introduction
Bioprinting offers the opportunity to reproduce tissue structures in-vitro to support the reconstruction of functional tissue constructs. Among the different bioprinting techniques, two photon polymerization (2PP) allows the generations of the smallest features up to the submicron range. However, the low volume throughput is the main drawback to obtaining constructs of a relevant...
Decellularized brain tissue combined with GelMa as a novel hydrogel emulating extracellular matrix in cerebral organoid-on-chips
Aysel Saskara1, Ozlem Yesil-Celiktas1,2,3
1 Department of Bioengineering, Faculty of Engineering, Ege University, 35100, Bornova, Izmir, Turkey
2 Translational Pulmonary Research Center (EgeSAM), Ege University, 35100, Bornova, Izmir, Turkey
3 ODTÜ MEMS,...
Gelatin Methacryloyl (GelMA) is widely used in biofabrication, yet its lack of reproducibility remains a major barrier for translation. This issue originates from a variety of reasons including inconsistent selection of raw materials, variations in modification strategies, varying degrees of substitution, and differences in solvent and photoinitiator concentrations employed in various studies....
