Conveners
S38 Advanced Organ-on-Chip Technologies for Pulmonary and microenvironment Studies
- Ozlem Goksel (EgeSAM-Ege University Translational Pulmonary Research Center)
- ลukasz Luลtyk (Warsaw University of Technology)
Introduction
With the escalating challenges of environmental pollution and climate change, research on chronic non-communicable diseases arising from exposure to various pollutants such as inorganic particles and micro-/nanoplastics has gained significant momentum. Among these, respiratory exposure to particulate matter, a major component of air pollution, has been strongly implicated in the...
Over the past 15 years, our group has focused on the development of advanced lung-on-chip (LOC) models that closely mimic the human lung parenchyma with high physiological relevance. Our early systems[1],[2], which replicated the three-dimensional deflection associated with physiological breathing motions, have since been commercialized by our spin-off company, AlveoliX. These foundational...
Introduction
The main defense mechanism against inhaled airborne particles is the epithelial barrier, consisting of lung epithelial cells connected by adherent junctions. While some airborne particles are eliminated by the innate defense system, those that are not detected, continue to progress in the body. In the long-term and high-concentration exposures the particles may escape the radar...
The undeniable impact of climate change and air pollution on respiratory health has led to
increasing cases of asthma, allergic rhinitis and other chronic non-communicable immunemediated
upper and lower airway diseases. Natural bioaerosols, such as pollen and fungi, are
essential atmospheric components undergoing significant structural and functional changes due
to industrial pollution and...
Introduction
Polymeric membranes, such as polyethylene terephthalate (PET), are widely used in Organ-on-a-Chip (OoC) systems due to their mechanical strength, porosity, and compatibility with microscopic analysis.[1] However, effective integration of these membranes into PDMS-based devices remains a technical challenge, as native PET does not readily bond with PDMS.[2] Surface modification is...
Efficient vascularization is critical for ensuring adequate nutrient and oxygen transport as well as metabolic waste removal in engineered tissues. Conventional strategies often depend on angiogenesis from existing vasculature, inherently limiting construct size and functional complexity. Nonetheless, the generation of structurally stable and perfusable constructs remains a significant hurdle...
Two-photon lithography (TPL) is a high-resolution technique capable of fabricating complex three-dimensional microstructures with sub-micrometer precision. Unlike conventional lithography methods, TPL allows freeform fabrication under ambient conditions, making it especially useful in biological applications where microenvironmental control is essential[1]. Its ability to produce structures...
