Speaker
Description
Biomolecule sensing is one of the most fascinating areas in the application of smart biopolymers. One of the most explored areas is the design of soft nanomaterials for glucose monitoring, which is of great significance in the diabetic therapeutic market. Multifunctional biomimetic, biocompatible, and smart materials based on hydrogels with physical properties similar to living tissues are of great significance. In this frame, to develop a platform for sensing the glucose in body fluids, facile and fast sensing, without any external energy and equipment play a vital role.
Here, a platform consisted of two outer layers of plasmonic hydrogel, and one electrospun mat as the inner layer was polymerized using UV light, providing a compact and stable device. Inspired from exceptional chameleon skin features, plasmonic silver nanocubes were embedded in poly(N-isopropylacrylamide)-based hydrogel network to achieve enhanced photothermal-responsive and antibacterial properties. Adequate mechanical and structural properties were provided in the system by the introduction of an electrospun mat into the hydrogel layers, which also creates a compatible environment for homogenous hydrogel coating.
Chemical, morphological and optical tests were performed to investigate the structure of layers and the proposed platform. The synergetic effect of thermo-responsivity and antibacterial properties, as well as sensing features of the nanostructured system, were investigated, revealing that the proposed system is a promising candidate for glucose sensing application.
Acknowledgments: This study was supported by the First TEAM grant number POIR.04.04.00-00-5ED7/18-00, which is conducted within the framework of the First TEAM programme of the Foundation for Polish Science (FNP) and co-financed by the European Union under the European Regional Development Fund.
References
[1] Xu, X.D., et al., Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, 81(2), pp.418-426, (2007)
[2] Eskitoros-Togay, et al., Fabrication of doxycycline-loaded electrospun PCL/PEO membranes for a potential drug delivery system. International journal of pharmaceutics, 565, pp.83-94, (2019)
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