Endogenous Bioelectric controls of growth and form


Michael, Levin


Embryos and regenerating systems produce very complex, robust anatomical structures and stop growth and remodeling when those structures are complete. How do cell collectives know what to build and when to stop? Control of this process would provide a radical solution to injury, cancer, and perhaps aging. In this talk, I will discuss new tools and data that are revealing how groups of cells use bioelectric networks to coordinate the building and repair of organs. I will show examples of molecular modulation of bioelectric signaling in vivo that enables regeneration of limbs and correction of complex birth defects. I will also discuss computational tools that are now enabling us to design combinations of ion channel drugs (electroceuticals) as a roadmap to regenerative medicine.

Presentation materials

There are no materials yet.