S35+S36 Giving meaning to early tissue damage responses in regeneration + Glycomodulation Approaches in Tissue Engineering
- Pauline Wosinski (Université de Paris, CNRS, INSERM, B3OA & Ecole Nationale Vétérinaire d'Alfort, B3OA )
- Johannes Grillari ()
- Abhay Pandit ()
- Heinz Redl ()
- Laura Russo ()
/The abstract will be added later due to patenting/
Embryos and regenerating systems produce very complex, robust anatomical structures and stop growth and remodeling when those structures are complete. How do cell collectives know what to build and when to stop? Control of this process would provide a radical solution to injury, cancer, and perhaps aging. In this talk, I will discuss new tools and data that are revealing how groups of cells...
Covalent carbohydrate conjugates, referred to as glycans, decorate the surfaces of all mammalian cells and are found on nearly half of all mammalian proteins. Proteins that recognize specific glycan structures, known as lectins, play a central role in decoding the information stored within glycans and converting this information into signals that direct changes in cell behavior. Galectins are...
"Regulatory T cells (Tregs) are immuno-suppressive cells which have been recently rediscovered as pro-regenerative cells. When accumulating in injured tissue, Tregs express numerous pro-healing factors such as anti-inflammatory molecules and cytokines. Interestingly, we found that a growth factor (GF) is expressed by Tregs across multiple injured tissues in the mouse. Therefore, we...
Multiple organs consists of macroporous structures such as the lung, bone, and kidney. However, when creating porous materials, added factors are quickly washed away, thus there is a need to bind them to the material.
Elastin-like Recombinamer (ELR) hydrogel is a type of biomaterial that has proved to have excellent biocompatible properties , where we here create a...
The repair and treatment of large bone defects in patients with compromised bone metabolism due to ageing and medical conditions such as osteoporosis present often a clinical challenge. Therefore adjunctive methods to enhance bone healing are needed. Bone tissue engineering with application of nanotechnology allows to construct biomaterials with desired properties being...