Speaker
Description
Intravital microscopy (IVM) has revolutionized our understanding of single-cell behavior in complex tissues by enabling real-time observation of molecular and cellular processes in their natural environment. In preclinical research, IVM has emerged as a standard tool for mechanistic studies of therapy response and the rational design of new treatment strategies. For understanding immune function in the tumor microenvironment, higher harmonic generation, a label-free multiphoton imaging technique, provides tissue context and reveals guiding structures which steer immune cell migration and modulate T cell efficacy. The talk will highlight the role of IVM for understanding cellular interactions with implanted materials and immune cell behavior in tumors within tissue-engineered bone.
