Intravital multiphoton and higher harmonic generation microscopy for visualizing cellular processes in cancer and tisseu engineering

Jun 30, 2022, 11:00 AM
20m
Room: S4 C

Room: S4 C

Speaker

Weigelin, Bettina (Werner Siemens Imaging Center, University Tübingen)

Description

Intravital microscopy (IVM) has revolutionized our understanding of single-cell behavior in complex tissues by enabling real-time observation of molecular and cellular processes in their natural environment. In preclinical research, IVM has emerged as a standard tool for mechanistic studies of therapy response and the rational design of new treatment strategies. For understanding immune function in the tumor microenvironment, higher harmonic generation, a label-free multiphoton imaging technique, provides tissue context and reveals guiding structures which steer immune cell migration and modulate T cell efficacy. The talk will highlight the role of IVM for understanding cellular interactions with implanted materials and immune cell behavior in tumors within tissue-engineered bone.

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