Selected technological and biological factors deciding about scaffold functionality

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ICE Krakow

ICE Krakow

ul. Marii Konopnickiej 17 30-302 Kraków


Kołbuk-Konieczny, Dorota (Institute of Fundamental Technological Research, PAS)


The quality of life of millions of patients has been improved by the development materials for regenerative medicine such as total knee joint prostheses, cardiovascular stents, orthopaedic implants, as well scaffolds for tissues regenerative. The global regenerative medicine market size is expected to reach USD 57.08 billion by 2027, growing at a CAGR of 11.27% over the forecast period.
In general, materials for regenerative medicine needs to be biocompatible, nontoxic, and fulfil properties suitable for specific application. Additionally, scaffold needs to fulfil different chemical and mechanical requirements due to differences in microenvironment of the impanation..
The aim of this presentation is to show selected research done in topic of crucial factors effecting scaffold functionality.
Fundamental research investigations about electrospun scaffolds development, structural and surface properties in terms of material-cells interaction will be analysed. We proved, electrospinning parameters and crystallinity degree play important role in cellular- material interaction.
Our second field of interest are grafts for ligaments reconstruction. Analyses of electrospun materials modified with growth factors were perform and effect of this modification on selected on gene expression of mesenchymal stem cells was analysed.
Finally I will present preliminary data from our last project “Preclinical study of the implant for reconstruction of the cruciate ligament with a substitute for bone regeneration”, acronym BioLigaMed (Small Grant NOR/SGS/BioLigaMed/0272/2020).

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