-
El Khatib, Mohammad (Unit of Basic and Applied Sciences, Faculty of Biosciences and Agro-Food and Environmental Technologies, University of Teramo)poster
Introduction: Advanced strategies in tendon Tissue Engineering might overcome the unsatisfactory results of conventional treatments for tendinopathies [1]. It aims at designing 3D tendon biomimetic scaffolds with adequate physical, mechanical, and biological properties of the native tissue. In this context, 3D tendon biomimetic poly(lactide-co-glycolic) acid (PLGA) scaffolds with highly...
Go to contribution page -
Gegenschatz-Schmid, Katharinaposter
Introduction:
Go to contribution page
Due to their favorable elastic properties, corrosion resistance and biocompatibility blood-contacting Nitinol is the material of choice for devices to treat cardiovascular diseases. A major drawback however is their strong thrombogenicity, making the use of systemic anticoagulation inevitable. Therefore, there is an urgent clinical need for reducing the thrombogenicity of... -
Whitehead-Clarke, Thomas (University College London)poster
Introduction: Fibroblast populated collagen matrices (FPCMs) are well established as a model for assessing the behaviour of fibroblasts. When used on a fixed substrate, FPCMs have also proven to be a reliable model for the study of tissue healing. Until now, such techniques have only been used with dermal fibroblasts to examine skin healing. Our work will develop a fixed (tethered) FPCM seeded...
Go to contribution page -
Alkildani, Said (BerlinAnalytix GmbH)poster
In addition to their chemical composition various physical properties of synthetic bone substitute materials have been shown to influence their regenerative potential and to influence the expression of cytokines produced by monocytes, the key cell-type responsible for tissue reaction to biomaterials in vivo. In the present study both the regenerative potential and the inflammatory response to...
Go to contribution page -
Meteling, Marieke (Leijten Laboratory, Department of Developmental BioEngineering, TechMed Centre, University of Twente)poster
Introduction:
Go to contribution page
One of the main methods to investigate cellular function, including stem cell differentiation, pathological state, and drug responsiveness, is by analysing deposition of extracellular matrix (ECM). Current methods such as Western blot, mass spectroscopy, or immunostaining, either require the removal of cells and processing of the ECM prior to analysis, or only allow for the... -
Giada, Bassi (1-Institute of Science and Technology for Ceramics (ISTEC) - National Research Council 2-University of Gabriele d'Annunzio, Chieti-Pescara)poster
Introduction. Osteosarcoma is the most common type of bone cancer diagnosed especially in children and young adults1. A combination of chemotherapy, radiotherapy and surgery is commonly used to treat this type of cancer2,3. In detail, chemotherapy is based on the use of molecules targeting the high cancer cell proliferation metabolism such as Platinum-based drugs that binds nuclear DNA upon...
Go to contribution page -
Martinez, Diana (Biomaterials group, Material Design Division, Faculty of Materials Science and Engineering, Warsaw University of Technology)poster
INTRODUCTION: Osteoblasts (OBs) and osteoclasts (OCs) interaction have an important role in bone remodeling [1]. Thus, coculture with both bone cells (OB-OC) is needed to achieve a better understanding of the material-cell interaction and the impact on Mg degradation for its potential use as a biomedical material. The aim of this study was to analyze the surface morphology and dynamic changes...
Go to contribution page -
Chuan-en, Lu (Institute of Biomedical Engineering, Department for Medical Technologies and Regenerative Medicine, Eberhard Karls University Tübingen, 72076 Tübingen, Germany)poster
Type 1 diabetes (T1D) is an autoimmune disease that leads to the destruction of pancreatic islets, resulting in the deficiency of insulin secretion. The current treatment is a daily insulin injection regimen, which negatively affects the quality of life for T1D patients and is difficult to manage over an entire lifespan. Therefore, an alternative treatment – islet transplantation within...
Go to contribution page -
Mota da Silva, Eduarda (Consiglio Nazionale delle Ricerche - Istituto di Fisiologia Clinica)poster
Introduction: Biomechanical features and osteogenic properties of magnesium implants make them suitable for orthopedic applications. [1] Commonly used in vivo methods to investigate tissue response, such as histology and gene expression of peri-implant tissue, are terminal procedures that give a limited temporal and spacial view on the organism response to the implant. [2] Thus, systemic...
Go to contribution page -
Ladner, Yann (AO Research Institute / ETH Zurich)poster
Introduction:
Go to contribution page
The in vitro differentiation of bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) to chondrocytes is mainly driven by the exogeneous administration of transforming growth factor β (TGF-β)[1]. Multiaxial load-induced activation of TGF-β1 (TGF-β1), which is secreted by the cells in a latent form has been shown to drive chondrogenesis[2]. In the present work, we apply a... -
S Pinho, Tiffany (Life and Health Sciences Research Institute, School of Medicine, Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal; Stemmatters, Biotecnologia e Medicina Regenerativa SA, Guimarães, Portugal)poster
Introduction: Electroactive smart materials are increasingly being used for tissue regenerative applications. Piezoelectric polymers, such as poly(vinylidene fluoride) (PVDF), are one type of electroactive materials that generate electrical potential fluctuations simply by applying mechanical pressure to the material, without the need for additional power sources. The use of piezoelectric PVDF...
Go to contribution page -
Nešporová, Kristina (Contipro a.s.)poster
Introduction: Implantable materials, e.g. barriers hindering the formation of peritoneal adhesions, are often produced from natural biopolymers. It is generally assumed that using biocompatible polymers such as hyaluronan (HA) will ensure the safety of the resulting product. But even products based on HA can elicit foreign body response (FBR) leading to their encapsulation (and thus to lower...
Go to contribution page -
Arianna, Rossi (1. Institute of Science and Technology for Ceramics (Istec- Research National Council) 2. University of Messina)poster
Introduction. Glioblastoma is a very aggressive type of cancer with a very poor life expectancy for patients and breast cancer often metastasizes into the liver, lungs, brain, and, in 70% of cases, to bones[1,2]. Chemotherapy is largely used to treat cancer and it is based on the use of molecules targeting the high cancer cell proliferation metabolism[3]. Platinum (Pt) and three of its...
Go to contribution page -
Chevallier, Nathalie (IMRB U955-E10, Inserm, Unité d'Ingénierie et de Thérapie Cellulaire-Etablissement Français du Sang, Université Paris-Est, Créteil, France)poster
Human bone marrow mesenchymal stromal cells (hBMSC) combined with biomaterials are currently used clinically for bone repair, but their bone formation kinetics are heterogeneous. The development of optimized pro-regenerative therapies requires a rigorous understanding of the molecular progression of regeneration. Here we report the divergent molecular events that drive hBMSCs toward fibrosis...
Go to contribution page -
Kołbuk-Konieczny, Dorota (Institute of Fundamental Technological Research, PAS)poster
The quality of life of millions of patients has been improved by the development materials for regenerative medicine such as total knee joint prostheses, cardiovascular stents, orthopaedic implants, as well scaffolds for tissues regenerative. The global regenerative medicine market size is expected to reach USD 57.08 billion by 2027, growing at a CAGR of 11.27% over the forecast period.
Go to contribution page
In... -
Genç, Hatice (1 Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Endowed Professorship for Nanomedicine, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erla)poster
Introduction: Living tissue is a very complex biological construct made of cells, signaling molecules and multiple extracellular matrix (ECM) components. Each of these elements is equally important to keep the homeostatic balance of tissue and to control the functions of organs. This heterogeneity of living tissues makes their engineering in laboratory conditions challenging 1. Biocompatible...
Go to contribution page
Choose timezone
Your profile timezone: