Conveners
S42 Microphysiological models as powerful preclinical tools
- Ozlem Yesil-Celiktas (Ege University)
Human liver tissue models are of great interest for toxicology analysis in drug development and as liver disease models. All solid tissues depend on sufficient oxygen supply for survival and on controllable oxygen tension for their proper function. Liver tissue models pose a particular challenge in oxygenation given the high oxygen consumption rate of hepatocytes and the well documented...
Age-related macular degeneration (AMD) is a chronic eye disease and the leading cause of irreversible vision loss in millions of elderly people world-wide. The ocular system implicated in this disease is the outer blood-retinal barrier (oBRB) comprised of the retinal pigment epithelium (RPE), the Bruch’s membrane (BrM), and the choriocapillaris (CC). The oBRB plays a pivotal role in...
"Introduction
Gut microbiota is able to communicate with the brain through complex bidirectional routes constituting the so-called microbiota-gut-brain axis (MGBA). Gut microbial dysbiosis increases local inflammation also thanks to the secretion of bacterial lipopolysaccharides (LPS), which disturbs the gastrointestinal and also the blood-brain barrier (BBB) permeability thus propagating...
"Introduction
Organ-on-a-chip (OoC) technology shows great potential to accelerate drug discovery and advance personalized medicine. Induced pluripotent stem cells (iPSCs) may enhance the predictivity of the OoC in the assessment of patient’s response to a pharmacological treatment and related toxicities. Nowadays, there are no body-on-a-chip fully based on iPSCs used for drug screening. In...
"INTRODUCTION
Rheumatoid arthritis (RA) is an autoimmune disease that affects diarthrodial joints, characterized by a systemic inflammatory response that leads to progressive joint destruction [1]. Various immune cells are involved, but the exact mechanism of RA development is still unknown, and it is well established that none of the currently available animal models fully represent human RA...
"Breathing exposes lung cells to continual mechanical stimuli, which is part of the microenvironmental signals directing cellular functions. Therefore, developing in vitro model systems that incorporate physiomimetic mechanical stimuli is urgent to fully understand cell behavior. This study aims to introduce a novel in vitro culture methodology combining mechanical stimuli that simulates in...
Multicellular tissues such as spheroids, organoids can be assembled in vitro from clusters of cells in a spatio-temporal manner, mimicking in vivo physiology and tissue microenvironment, which can leverage pre-clinical evaluation of the efficacy and safety of potential new drugs for diseases such as hereditary, neurodevelopmental, infectious and cancer. In one approach, immortal, primary or...
