Conveners
S45 Nature bioinspired biomaterials and strategies for TERM
- Thomas Groth (Department Biomedical Materials, Martin Luther University Halle-Wittenberg)
- Nuno Neves (3B's Research Group / University of Minho)
"Introduction: The acquisition of neural signals from the brain cortex has always been of high relevance in the field of neuroscience in order to analyze and interpret brain processes as well as individuate neurological diseases and disorders [1]. Nowadays, the design of a neural interface conformable with the brain tissue is one of the major challenges, since the inadequate conformability...
Background: intrahepatic islet transplantation in patients with T1D is limited by donor availability and lack of engraftment. To overcome these limitations, based on our experience with decellularized rat lung as scaffold for the generation of Vascularized Islet Organ (VIO, lung scaffold repopulated by murine islets and HUVEC cells), we engineered an upgrade based on human blood-derived...
"Four-dimensional (4D) bioprinting (i.e., fabrication via additive manufacturing of scaffolds characterized by a programmed change, over time, under a predefined stimulus [1]) can be exploited to produce active scaffolds that can modify their shapes upon desired stimulation, thus potentially recapitulating biological processes such as morphogenesis.
In this study, we exploited the 4D...
"Micro- and nanofibrous materials have attracted the interest of the scientific community for the better part of ~30 years, due to their unique properties and potential for applications. Electrospinning is a technique that can produce micro- and nanofibers fast, repeatedly, and with tailored morphology. When fibres are electrospun from biocompatible polymers then they can be used in numerous...
"Bone tissue regeneration (BTR) has been trying to mimic the bone environment in biofabricated platforms. Given the complex bone metabolism, creating a functional, differentiated and biologically compatible platform that stimulates tissue formation in an autonomous way is currently a challenge [1]. Therefore, the development of multifunctional micro-platforms easy to produce and to translate...
"Introduction
Tissue growth in defects is controlled by the local curvature of the substrate and is traditionally regarded to follow the same process of cell organization from large to small defects [1]. At defect dimensions of 100s of µms to a few mms, tissue growth typically follows a centripetal process driven by an inner ring composed of contractile and proliferative cells. In contrast,...
"Introduction: One of the most challenging and daunting task of tissue engineering is the assembly and integration of functional microvasculature systems within the biofabricated tissue equivalents. Having functional vasculature is of the utmost importance to promote the rapid integration of the host’s microvasculature with the engineered one present in the graft, thus enabling an efficient...
