Conveners
S46 New developments of regenerative and tissue modeling products
- Xanthippi Chatzistavrou (Michigan State University )
- Faleh Marino
Three-dimensional (3D) bioprinting has emerged as a class of promising techniques in biomedical research for a wide range of related applications. Specifically, vat-polymerization techniques such as digital light processing (DLP), are highly effective methods of bioprinting, which can be used to produce high-resolution and architecturally sophisticated structures. Nevertheless, conventional...
Leveraging advances in biomaterials and tissue engineering, it is becoming possible to develop successful reparative, regenerative and tissue modelling solutions. Over more than two decades, we have made progress with studying biodegradable materials for reparative medicine. For example, biodegradable screws and plates were translated to the clinic as osteosynthesis implants. Scaffolds for in...
"Introduction
Laryngeal cancer is often diagnosed at an advanced stage when treatment options are limited and most often restricted to laryngectomy. As this procedure requires a permanent tracheostoma, it is associated with additional complications such as a high risk of infection, fistulae formation and loss of the natural voice. In addition, restoration of the most important laryngeal...
"Background: Hypospadias is a common congenital abnormality with varying severity. There may be lack of local tissue during hypospadias surgery. Oral mucosa (OM) is widely used for urethroplasties and repair after failed hypospadias in adults. Little is known about the applicability of OM in prepubertal boys because of eventual hormonal effect of puberty on OM. We investigated the androgen...
"Skin ageing is a multifactorial process attributed to both intrinsic and extrinsic factors. Intrinsic ageing is associated with changes that occur with age such as cumulative molecular and cellular damage, while extrinsic ageing exacerbates these changes through the UV exposure. Nowadays, ageing has become an important issue in the world: life expectancy and population have increased, while...
Introduction: Three-dimensional bioprinting (3DBP) relies on extrusion-based methods for the printing process, however such methods are known to reduce cell viability due to the introduction of shear forces during extrusion. Additionally, the incorporation of solid elements into bioinks such as ceramic particles that may support bone growth, leads to increased shear forces during 3DBP leading...
INTRODUCTION: Vascular endothelial growth factor (VEGF) is the principal regulator of angiogenesis. Tightly bound gradients to extracellular matrix determine the microvascular endothelial cells fate during organogenesis and tissue regeneration and uncontrolled expression can lead to abnormal vascular growth and vascular tumours 1. Despite advances in tissue engineering, tight spatio-temporal...
"For achieving early intervention treatment to help patients to delay or avoid joint replacement surgery, a personalized scaffold should be designed coupling the effects of mechanical, fluid mechanical, chemical and biological factors on tissue regeneration, which results in time-consuming and cost-consuming trial-and-error analyses to investigate in vivo test and related experimental...
