Conveners
S59+S18 The role of multifunctional nanomaterials in new tissue regeneration strategies + Biomedical applications of MXene based next generation nanomaterials
- Aleksandra Benko (AGH University of Science and Technology)
- Sanjiv Dhingra (Institute of Cardiovascular Sciences, University of Manitoba )
- Lucia Gemma Delogu
Nanotechnology is now found in almost every aspect in life, from the liposomes that carry COVID-19 vaccines to coatings placed on floors to reduce wear. Over the past 20 years, the use of nanotechnology in medicine has grown from the unknown to now significantly helping to prevent, diagnosis, and treat numerous diseases. This is true for regenerative medicine and tissue engineering as well....
Synthetic hydroxyapatite is therapeutically used as bone graft substitute, bone filler, or as coatings to support attachment of bone to metal implants. Here I will present some data on how our group have used hydroxyapatite nanoparticles in combination with various polymers and fabrication techniques to support bone cell differentiation and matrix formation in both static and mechanically...
"Introduction
Efficient regeneration of different tissue types requires solutions that are specifically tailored to meet certain criteria. This is particularly true for the group of hard-to-regenerate tissues, such as cardiac, neural or chondral, which are known to have a low self-regeneration potential. The cells of these tissues often require certain factors to induce their division,...
"Introduction
In situ tissue-engineered vascular grafts (TEVGs) based on resorbable synthetic scaffolds have the potential to overcome the limitations of prosthetic graft replacement and provide off-the-shelf availability. Despite massive efforts in investigating new materials, up to date no TEVG is clinically available. One of the most important challenges for successful regeneration is to...
Introduction: Allograft vasculopathy is an aggressive form of accelerated atherosclerosis that manifests uniquely in transplanted hearts, lungs, and kidneys. Activated blood vessel endothelial cells (ECs) stimulate alloreactive CD4+ and CD8+ T-lymphocytes to result in sustained inflammation. Transition metal carbides, MXenes, are an emerging class of nanomaterials that have recently been shown...
Introduction
Spinal cord injury (SCI) is a devastating condition that disrupts both sensory and motor function, with very limited prospects of functional recovery. Electrical stimulation (ES) has become a common clinical remedy to lessen the impact of SCI-induced pain after injury. However, regeneration-focused lesion site electrostimulation has not had clinical translation yet, despite...
Introduction:
Lack of a cornea’s donor is still a huge problem in ophthalmology leaving over 98% of people waiting for the transplantation. As the solution, bioengineered scaffolds, mimicking the fibrous structure of the corneal stroma are proposed. To obtain a full regeneration, such substrates should provide both cornea cells repopulation and optical transparency. In the native cornea, the...
"Polymer scaffolds are playing an increasing role in tissue engineering (TE), although there is still a need to improve their biomimicry of cellular microenvironments, by having smart scaffolds with an active response, which can improve tissue regeneration. Ionic liquids (ILs) have emerged as an attractive option to achieve this due to the biodegradability and biocompatibility of many ILs, and...
