Conveners
S65-1 Vascularization for Tissue Engineering and Regenerative Medicine
- Zygmunt Pojda
Therapeutic angiogenesis, i.e. the generation of new vessels by delivery of specific factors, is required both for rapid vascularization of tissue-engineered constructs and to treat ischemic conditions. Vascular Endothelial Growth Factor (VEGF) is the master regulator of angiogenesis. However, uncontrolled expression can lead to aberrant vascular growth, as well as non-vascular side-effects....
"ENGINEERING HIGH DENSITY CAPILLARY-LIKE NETWORKS USING MICROPOROUS ANNEALED PARTICLE TISSUES
M.R. Schot1, C.A. Paggi1, M.L. Becker1, J. Leijten1
Presenting author: Maik Schot, m.r.schot@utwente.nl
1Department of Developmental BioEngineering, TechMed Centre, University of Twente, the Netherlands
INTRODUCTION: The vascular tree is essential for the function and survival of tissues....
"Introduction. Coupling of angiogenesis and osteogenesis is crucial to generate vascularized bone grafts. Semaphorin 3a (Sema3a) regulates osteoblasts and osteoclasts to promote bone synthesis through Neuropilin-1 receptor (NP1). We previously found that: 1) short-term delivery of Vascular Endothelial Growth Factor (VEGF) in osteogenic grafts dose-dependently decreases bone formation by...
"Introduction
The ultimate goal in vascular tissue engineering is the generation of bioartificial blood vessels that resemble the morphology and function of native vessels as accurately as possible. Previous studies have shown that the tunica intima and tunica media of native blood vessels can be resembled in bioartificial vessels by applying physiological mechanical stimulation using...
"Introduction: Vascularization is crucial for proper implant survival and integration in the body. For an implant to be vascularized in vivo and thereby supplied with oxygen and the needed nutrients, the body’s blood vessels have to invade the implant first. This is a very slow and often insufficient process, especially in thicker tissues, which can result in implant loss. A solution for this...
"Introduction: The lack of functional vascular networks is one of the most important hurdles in tissue engineering, limiting the obtainment of fully functional organs substitutes. Vascularization promotes efficient nutrients and oxygen supply, representing a key factor for in vivo application [1]. Endothelial cells not only act as the structural building blocks of vascular endothelium, but...
"Introduction
One of the key challenges in the field of tissue engineering is the vascularization of tissue-engineered constructs. Until now, endothelial cells (ECs) derived from human umbilical cord have been the predominant EC type for the engineering of vascularized tissue. However, ECs of different origins display a great heterogeneity, reflecting in tissue- and organ-specific...
"Vasculature plays an essential role in skin physiology and its architecture and function are altered in aged and diseased skin. There is thus a need to develop innovative 3D in vitro models with adjustable and amenable vasculature. Several in vitro skin models co-seeding endothelial cells with fibroblasts and keratinocytes have been proposed using scaffolds or bioprinting. However, they all...
"The biofabrication of living constructs containing hollow channels is critical for manufacturing thick tissues. Current technologies are limited in their effectiveness in the fabrication of channels with diameters smaller than dozens of micrometers.
Here we present advances in continuous chaotic bioprinting, an additive manufacturing technique that enables the creation of complex biological...
Nowadays, the main approaches to engineer vascularized tissues are to develop biomaterials combining with cell-based therapy to achieve rapid vasculogenesis angiogenesis and anastomosis between engineered and host blood vessels. However, the thickness of engineered vascularized tissues in animals were still less than 1 mm, because the hydrogel becomes less permeable with increasing thickness....
