Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2022

Session

PS32 Extracellular vesicles for soft tissue repair

PS32

Not scheduled

ICE Krakow

460. Adipose stem cell secretome as a potential treatment for urethral fibrosis

Barasa, Povilas (Vilnius University, Life Sciences Center, Institute of Biochemistry )

poster

Urethral fibrosis affects 1 out of 1000 individuals within their lifetime, most of those affected being male. It shares the hallmarks of other types of fibrosis (e.g., liver or heart), namely, the activation of myofibroblasts, overabundance of collagen and the spread of scarring from the initial focus to the surrounding tissue, leading to organ failure. It can be caused by trauma, infection...

457. EXTRACELLULAR VESICLES DERIVED FROM AMNIOTIC FLUID MESENCHYMAL STEM CELLS SELECTED BY SKIN TISSUE TYPE MARKERS REDUCE INFLAMMATION

Talts, Jan (Amniotics AB )

poster

Introduction
One of the main stages during wound healing is inflammation. There are indications that extracellular vesicles (EV) from mesenchymal stem cells (MSC) can ameliorate inflammation during this process. MSC have immunomodulatory properties and can induce regeneration. MSC from various sources have been used in wound healing studies. Moreover, several studies have demonstrated that...

462. Influence of interleukin -10 on effects elicited by human MSC transplantation in mice with experimental influenza virus - induced pneumonia

Pokholenko, Ianina (Institute of Molecular Biology and Genetics of NAS of Ukraine )

poster

Introduction. Interleukin 10 (IL-10) is anti-inflammatory cytokine that plays central regulatory role in immune-mediated inflammation caused by viral infection. The purpose of this work was to study the action of IL10 on the efficiency of cell therapy in a mouse model of influenza pneumonia.
Methodology. We used an experimental model of influenza pneumonia obtained by intranasal infection of...

461. Mesenchymal stromal cells-derived extracellular vesicles: from 2D to 3D

Federica Palama, Maria Elisabetta (DIMES University of Genoa )

poster

Introduction
The secretion of therapeutic factors and extracellular vesicles (EVs) by mesenchymal stromal cells (MSCs) gained much interest for their benefits in the regenerative medicine field. Indeed, the in vitro multipotency of these cells and the secretion of both angiogenic and immunomodulatory factors suggest a role in tissue repair and regeneration. However, during culture in...

463. THE BIOACTIVITY OF PLATELET-RICH FIBRIN CONDITIONED MEDIUM ON ZOLEDRONATE-INDUCED ORAL KERATINOCYTE TOXICITY IN VITRO

Rattanawonsakul, Krit (Department of Materials Science and Engineering, The University of Sheffield)

poster

Introduction:
Medication-related osteonecrosis of the jaw (MRONJ) is an adverse effect of bisphosphonate therapy which is characterised by the loss of overlying soft tissue and exposure of necrotic bone in the oral cavity1, affecting the quality of life of patients2. The lack of effective treatment approaches3 leads to the development of alternative therapies including platelet-rich fibrin...