Urethral fibrosis affects 1 out of 1000 individuals within their lifetime, most of those affected being male. It shares the hallmarks of other types of fibrosis (e.g., liver or heart), namely, the activation of myofibroblasts, overabundance of collagen and the spread of scarring from the initial focus to the surrounding tissue, leading to organ failure. It can be caused by trauma, infection...
Introduction. Interleukin 10 (IL-10) is anti-inflammatory cytokine that plays central regulatory role in immune-mediated inflammation caused by viral infection. The purpose of this work was to study the action of IL10 on the efficiency of cell therapy in a mouse model of influenza pneumonia.
Methodology. We used an experimental model of influenza pneumonia obtained by intranasal infection of...
Introduction
The secretion of therapeutic factors and extracellular vesicles (EVs) by mesenchymal stromal cells (MSCs) gained much interest for their benefits in the regenerative medicine field. Indeed, the in vitro multipotency of these cells and the secretion of both angiogenic and immunomodulatory factors suggest a role in tissue repair and regeneration. However, during culture in...
Introduction:
Medication-related osteonecrosis of the jaw (MRONJ) is an adverse effect of bisphosphonate therapy which is characterised by the loss of overlying soft tissue and exposure of necrotic bone in the oral cavity1, affecting the quality of life of patients2. The lack of effective treatment approaches3 leads to the development of alternative therapies including platelet-rich fibrin...
