Introduction
The bone marrow (BM) is a dynamic organ whose main function is to support haematopoietic cells, which assure life-long production of blood. The haematopoietic compartment is supported by the stromal fraction of the BM that comprises mesenchymal stromal cells (MSCs), a heterogeneous cell population that undergoes osteogenic, chondrogenic, adipogenic differentiation. Following a...
Introduction
The overall burden of osteoarthritis (OA) in the US is estimated at $136.8B annually, an amount that surpasses that of tobacco-related health effects, cancer, and diabetes. Current interventions are not effective in arresting the progressive cartilage degeneration. Stem cell therapy is the new frontier for OA treatment. Intra-articular injection of mesenchymal stem cells (MSCs)...
Introduction: The studies of MSCs therapeutic action have been conducted over the past 20 years for a variety of human pathologies, both in model experiments in animals and in clinical trials. However, there are very few studies on the effects of MSCs in viral infections. Thus the present work aimed to study the effects of MSCs administration at the very beginning of the acute phase on the...
INTRODUCTION: One of the main causes of stroke in acute cerebrovascular accident is ischemia, which begins with the formation of acute neuronal energy deficiency with subsequent activation of "ischemic cascade" reactions, which leads to irreversible damage in nerve tissue. But the restoration of perfusion of ischemic tissue contributes to the deepening of metabolic disorders in the brain,...
Treating immune-related diseases, which incidence is steadily growing, is still a challenge. Among the new treatments under development, mesenchymal stromal cell (MSC) transplants seem to be one of the most promising. Although MSC-based therapies are being implemented into the clinic, many aspects regarding these procedures requires further optimization. A new trend in translational medicine...
Breast cancer (BC) is the most common cancer and the fifth leading cause of death according to World Health Organization. Surgery is the main treatment for BC. After primary cancer-mass excision, in a high percentage of the cases, some breast cancer cells (BCC) with tumorigenic potential remain dormant/quiescent. In worst scenarios, dormant-BCC lose quiescence and re-activate their tumorigenic...
Introduction. In modern medicine, the transplantation of mesenchymal stem cells (MSC) is utilized as a universal system for organism’s protection and renewal under normal and pathological conditions. However, there are only a few studies concerning the use of mesenchymal stem cells to treat respiratory viral infections. This study aimed to estimate the morphological direction of MSC action in...
Introduction Mesenchymal stem/ stromal cells (MSCs) represent one of the most extensively investigated adult stem cell populations due to their pro-regenerative activity observed following their application into injured tissues. Diabetes mellitus type 2 (T2D) is a serious civilization disease occurring frequently in western societies. The prolonged high glucose level in blood may cause damage...
Mesenchymal stromal cells (MSCs) possess immunomodulatory abilities that make them a promising candidate for the treatment of immune-mediated diseases, particularly those with an autoimmune component. We have recently shown that preconditioning human bone marrow (BM) MSCs with Vadadustat – hypoxia mimicking agent, may constitute a valuable approach to improve the therapeutic properties of...
Mesenchymal stem cells (MSCs) represent a promising tool for tissue engineering and regenerative medicine. However, their procurement often requires invasive medical procedures. Urine-derived stem cells (UDSCs) display similar properties to MSCs, and their sampling and further processing are non-invasive for donors. The goal of this study was to analyze their morphology and selected biologic...
Introduction
Mesenchymal stem cells (MSCs) are self-renewing, non-specialized, multipotent cells with great potential to differentiate into various tissue cells. Due to their secretion activity, migration, adhesion and homing abilities, MSCs are currently highly investigated stem cells and the one most commonly used in regenerative medicine. The use of adult MSC is still challenging, since a...
Introduction
Allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice for malignant blood diseases. However, long-term results are limited by the high morbidity and mortality associated with the development of graft versus host disease (GVHD). The use of mesenchymal stem cells (MSCs) has emerged as a safe and effective therapeutic option for GVHD due to its...
Mesenchymal stromal cells (MSCs) have shown great promise in experimental traumatic brain injury (TBI), conferring protection mainly through the release of bioactive factors (secretome). In vitro models, mimicking the in vivo condition in a simpler but representative environment may be fundamental to investigate secretome mechanisms of action. Nonetheless, TBI research lacks relevant 3D in...
OXIDATIVE STRESS RESPONSE IN ADIPOSE-DERIVED MESENCHYMAL STEM/STROMAL CELLS
Tawakalitu Okikiola Waheed, Olga Hahn, Kaarthik Sridharan, Nina Gehm, Caroline Moerke, Kirsten Peters
Introduction: Adipose tissue-derived mesenchymal stem/stromal cells (adMSC) are shown to support wound healing due to their regenerative and immunomodulatory capacities. However, cell survival in the specific...
Introduction: Numerous clinical trials in which MSC cells were used have lead to different results, not always as positive as expected. According to our hypothesis MSC can be replaced in some therapies by active factors they produce. Therefore, we decided to replace the primary MSC cultures with immortalized line derived from human adipose tissue (HATMSC1) to produce biologically active...
Introduction: The enhancement of mesenchymal stem cells (MSC) therapeutic potential is considered an important scientific task. Though it was demonstrated, that pre-conditioning with interferon-γ (IFNγ) is able to enhance the MSC immunomodulatory properties, no current data is known from literature about the effects of interferon-α (IFNα) on MSC. The aim of the present study was to evaluate...
Introduction
Cardiovascular disease (CVD) is a general term for a group of disorders of the heart and blood vessels. According to statistical data of World Health Organization (WHO), CVD is one of the most prevalent disease and the leading cause of death globally in recent years. Therefore, it is justified to search for new, effective therapeutic methods such as stem cell therapy and tissue...
Introduction:
One of the most common labor disturbances is the reduction of prenatal blood flow which results in reduction of oxygen level in neonatal brain. This in turn can lead in long term to the development of drug-resistant epilepsy. Main therapy in the case of epilepsy is administration of sedative drugs which alleviate degree of seizures but also decline the child’s cognitive...
