INTRODUCTION
Biophysical parameters are integral to various pathophysiologies, such as fibrosis and cancer. Systematic investigations of such parameters and how they influence cell behaviour and disease progression are feasible in 3D in vitro models of disease.
In this project we used collagen I, the most abundant extracellular matrix protein, to engineer 3D constructs, both as soft...
Biomedical research is in need of evolving towards more sustainable models by adopting the concept of the three Rs (reduction, refinement, replacement of animals in research). Additionally, economic limitations in developing countries should also be taken into consideration. This project aims to develop a non-animal sourced and low-cost biomaterial that can be used to create accurate tissue...
Symposium: Cell-rich constructs for tissue engineering.
Introduction: The development of in-vitro model of skeletal muscle regeneration is extremely challenging. Human Bone Marrow-derived Mesenchymal Stem Cell (hBM-MSCs) and human Myoblast co-culture with growth factor supplementation has been described for in vitro myogenic commitment [1-2]; among them, b-Fibroblast Growth Factor (b-FGF) was...
Introduction
Tissue engineering entails the combination of mechanical, chemical and biological components to process materials that can be engineered towards artificial tissue structures in order to mimic the natural microenvironment of cells; the extracellular matrix (ECM), which provides cells with structural support as well as biochemical, biophysical, and mechanical cues. Biomaterials...
