Introduction: In bone tissue engineering, several attempts have been made to generate artificial bone constructs to replace the autograft and allograft treatment and to enhance bone repair and regeneration. However, engineering bone tissue presents some challenges, mainly based on bone tissue’s gradual variation of several biological, mechanical, and structural features. Another challenge is...
TITLE: A study on hBM-MSCs chondrogenic commitment by 3D Collagen scaffold loaded with PLGA nanocarriers for TGF-β1 controlled release
AUTHORS: Lamparelli Erwin P.1, Lovecchio J.2, Giordano E.2, Maffulli N.1, Della Porta G. 1,3(*),
1 Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, Baronissi (SA), Italy
2 Department of Electrical, Electronic and...
This study developed novel stimuli responsive injectable hydrogels composed of a biocompatible and anti-adhesive cartilage acellularized matrix (CAM) and a diselenide bridge-containing cross-linker by using norbornene (Nb)-tetrazine (Tz) click chemistry. The crosslinking reaction between CAM-Nb and the Tz-cross-linker evolved nitrogen gas and resulted in injectable hydrogels with highly porous...
This work is based on the functional coupling of integrins, boron (B) transporter (NaBC1), and growth factor receptors (GFR) after their activation. In our previous work, we have demonstrated that active-NaBC1, co-localise with fibronectin-binding integrins (α5β1/αvβ3) and GFR producing a functional cluster that synergistically enhances biochemical signals and crosstalk mechanisms,...
Introduction: Hydrogels are promising biomaterials for regenerative medicine due to their flexible shape, resemblance with the extracellular matrix and capacity to deliver and release bioactive compounds. Especially, injectable hydrogels gained popularity due to their minimal invasive application [1]. Fucoidan is a sulfated polysaccharide from the cell wall of brown algae with multiple...
There is still need for development of biomimetic hydrogels capable to recapitulate the native environment of bone tissue, as those used currently lack of tissue-specific composition and yield suboptimal tissue formation. Decellularized extracellular matrix (dECM) is composed of tissue-specific biopolymers and growth factors. Moreover, it undergoes gelation at physiological temperatures....
Introduction:
Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) play an important role in cell physiology, cell-cell communication, and immunomodulation. EVs are promising for regenerative medicine1, but their therapeutic effect in vivo is reduced due to their rapid clearance and short half-life2.
Injectable hydrogels emerged as great bioactive compound carriers due to...
Material-Assisted Bioengineering Strategies for Osteochondral Defect Repair
Constance Lesage, Marianne Lafont, Pierre Guihard, Pierre Weiss, Jérôme Guicheux, Vianney Delplace
*Theses authors contributed equally to this work
Key words: osteochondral defect, cartilage, subchondral bone, regenerative medicine, biomaterials, cell therapy, biologics
The osteochondral (OC) unit,...
Although fibrosis is a natural process with a protective function in the body, it can lead to progressive disease and eventual loss of organ function. This pathology can affect different tissues, ranging from skin to the heart; indeed, lung fibrosis has been observed in COVID-19 patients. The proposed root causes of fibrosis are injury, infection and chronic inflammation, which leads to...
Injured neural tissue after the intracerebral hemorrhage (ICH) stroke has limited endogenous regeneration because of inflammation and cell apoptosis. The brain cavity and neural scar tissue caused by the hematoma often lead to a permanent behavior disability. Biomaterials can serve as temporary supporting matrices and promote brain tissue regeneration. A chitosan-based self-healing hydrogel...
Introduction
The atrioventricular block constitutes a common congenital disease among pediatric patients. Nowadays the treatment requires repetitive operations for the placement and replacement of technical pacemakers influencing the life quality of young children. In our project, we developed a tissue engineered solution with the aim to avoid the technical pacemakers and therefore the...
