CERIUM, ZIRCONIUM AND COPPER DOPED ZINC OXIDE NANOPARTICLES FOR BONE REGENERATION AND ANGIOGENESIS
H Akhtar1, J A Darr2, T Ashton2 , AA Chaudhry3, and I U Rehman4 & GC Reilly1
hakhtar2@sheffield.ac.uk, j.a.darr@ucl.ac.uk, t.ashton@ucl.ac.uk, aqifanwar@cuilahore.edu.pk, i.u.rehman@lancaster.ac.uk, g.reilly@sheffield.ac.uk.
1 INSIGNEO institute for in silico Medicine, University of...
Introduction
Extracellular matrix (ECM) of hard tissues in human body has a specific composition combining organic and inorganic fractions that determines their properties and function. Therefore, designing scaffolds for bone tissue regeneration we should consider hybrid materials providing proper mechanical and structural support. The focus of current study were scaffolds based on...
Biodegradable magnesium alloys are promising candidates for temporary fracture fixation devices in orthopedics; nevertheless, its fast degradation rate at the initial stage after implantation remains as one of the main challenges to be resolved. ZrO2-based coatings to reduce the degradation rate of the Mg-implants are an attractive solution since they show high biocompatibility and stability....
Introduction
Bone loss due to various infections, aging, tumors or genetic disorders is worldwide problem; moreover, not all defects can be regenerated by using today’s technologies. For this reason scientists construct artificial bone scaffolds which could provide new bone treatment strategy. Scaffolds surface biodecoration highly enhances their integration and allows to control damaged...
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Bone is one of the most important composite building materials, which is the main component of the human skeleton [1]. It is estimated that the total number of fractures in the European Union will increase from 2.7 million in 2017 to 3.3 million in 2030. The resulting annual costs associated with fractures are expected to increase by 27%. Furthermore, as the population ages, this figure is...
The growing interest in finding the best way to strengthen Mg alloys has recently focused on the development of Mg-Y-Zn alloys with long-period stacking ordered (LPSO) structures [1]. The microstructure of Mg-Y-Zn containing LPSO structures formed during plastic deformation was found to be beneficial in terms of mechanical properties [2]. The goal of this work is to investigate the role of...
Introduction. Bone is the second most commonly transplanted tissue. The problems with allografts and xenografts as substitute for original tissue are associated with the graft loosing, inflammation and osteolysis or the death of bone tissue, which only adds to the existing damages [1,2]. In order to solve these shortcomings, tissue engineering have suggested a number of potential therapeutic...
Large bone defects remain a clinical challenge to be solved via emerging 3D scaffolds. For effective treatments, the bone scaffold should satisfy competing mechanical, biological, and chemical functions presenting a challenging design problem. Besides mainstream experimental studies, computational efforts exist in literature presenting scaffold designs with primarily optimized geometries...
So far, most organ and tissue damage resulting from genetic defects or trauma is treated with either pharmacologically or surgically. This is performed through the use of appropriate drugs or, in more severe cases, organ transplantation. However, over the past few years, biomaterials have increasingly gained importance in materials science with great hopes for solving tissue and organ healing...
INTRODUCTION: Millions of bone reconstruction operations are conducted every year. A promising alternative to autologous bone grafts are customized bone scaffolds. Biofunctional custom implants fills the defect in the tissue and carry mechanical loads. The presence of groups with hydrophilic properties (e.g., -OH) on biomaterial surface is preferred. For this reason, the modification of the...
Along with the continuous development of civilization and the intensive technological progress, the diseases of civilization are becoming a growing problem. The most common diseases of civilization include cardiovascular diseases, cancer and osteoporosis [1]. According to the International Osteoporosis Foundation, the problem of osteoporosis affects approx. 200 million people. Osteoporosis is...
Introduction: Synthetic hydrogels are a promising strategy to reproduce the 3D microenvironment of bone tissue. However, most of them lack the required bioactivity to actively influence cell fate. To this end, biochemical cues, such as integrin-binding molecules combined with growth factor derived sequences, may be installed on hydrogels to mimic bone extracellular matrix (ECM) [1-2], thus...
Tissue engineering faces a major challenge in providing novel, functional materials that will meet the requirements of tissue engineering. These properties can be provided by tricalcium phosphate-based bioceramics (TCP). The combination of a ceramic matrix with polymers creates great opportunities to improve the physicochemical and biological properties of the obtained composites....
Chitosan is a well-known polymer widely used in tissue engineering and regenerative medicine. It is biocompatible, biodegradable, non-toxic, has antibacterial and osteoconductive properties. It is perfect for the production of implantable materials, including porous scaffolds. Unfortunately, as with most natural polymers, chitosan structures exhibit poor mechanical properties, low durability,...
