The circulation of Ptolemaic coins in Asia Minor, particularly in southwestern Asia Minor, where the political hegemony was mainly established, has never been studied in detail. In addition to the published material, new numismatic data, both from archeological excavations and museum collections which make such a study possible, offer new evidence for making new attributions as well as for revisiting the existing ones. The study of this new data makes it possible to propose new mint attributions for some coin issues previously described as “Uncertain mint(s)”. Moreover, the circulation of Ptolemaic coins in the region adds to our understanding of the rise and the decline of the political hegemony. This study is mainly based on Ptolemaic coins from excavations and museums in Caria and Lycia.