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A first computational investigation of electric field distributions generated by magnetoelectric nanoparticles (MENPs) is presented in this work in the context of neural tissue modulation. Our study employed a dual-modeling approach to analyze both individual particle behavior and collective effects at tissue level in 2D plane and 3D volume of nerve tissues. Results demonstrate that MENPs at 0.1% w/v concentration generate electric fields reaching therapeutic thresholds for neuromodulation, with 3D distribution achieving 20.66% tissue coverage above 10 V/m compared to 4.12% in 2D arrangement. The study reveals that 3D MENP distributions provide better field coverage while maintaining the advantages of wireless, targeted stimulation with sub-millimeter precision.
