Speaker
Description
The involvement of magnetic fields in basic cellular processes has been studied for years. Intensity has long been the central parameter in hypotheses of interaction between cells and magnetic fields, however, biological systems are not linear and an increase in intensity does not always increase the occurrence of cellular effects. The main objective of this article is to obtain a specific combination of parameters (frequency, intensity, time) to reduce the viability and proliferation of various tumor cell lines. In addition, the “dose effect” theory is tested to determine whether an increase in intensity increases the cellular effects found. Different tumor (CT2A, B16F10, SKBR3, MDA-MB-231, PC12) and non-tumor (astrocytes, C8-D1A) cell lines are exposed to a magnetic field variable in time (acute: 3-24 hours; chronic: 96-120 hours) and intensity (10-1000 µT) using a frequency of 50 Hz and a square waveform. The results fit a biological window model in which the viability and proliferation of cells decrease statistically significantly in a window of values centered dependent on the type of cell used. Specific values of time and magnetic field intensity are found at which viability and proliferation decrease considerably. The cellular behavior does not comply with the so-called “dose effect” and exposures to higher intensities do not necessarily lead to a greater occurrence of the effects on the cellular processes studied. These results are important in a possible therapeutic application of magnetic fields for different pathologies such as cancer or neurodegenerative diseases taking advantage of the so-called “therapeutic window”.
