Speaker
Description
Delivering low-intensity electrical currents through scalp electrodes, using transcranial Direct Current Stimulation (tDCS) can modulate the membrane potential of cortical neurons and may potentially restore the balance of excitability in epileptogenic networks. Optimizing the efficacy of tDCS to decrease the frequency of seizures requires a better understanding of tDCS impact on brain dynamics at both local and network levels. The aim of this study is to develop a pipeline integrating finite element method (FEM) modeling of tDCS electric fields and neural mass models, and to evaluate the effects of these weak electric fields on the activity of epileptogenic networks. Bridging field simulations with network-level dynamics offers insights into the mechanisms of tDCS and its potential optimization as a therapeutic tool for epilepsy. Results show changes in network connectivity and a decrease in the activity of the propagation zones post-stimulation.
