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The expansion of 5G and WiGig millimeter waves (MMW) has raised concerns about potential health effects from radio frequency (RF) exposure. While previous studies focused on eyes and cultured cells, little research has examined MMW effects on living skin. Since MMWs penetrate only a few millimeters, their histological effects are crucial. This study exposed anesthetized rats to 26.5 GHz quasi-MMW (0–1020 W/m², 18 min). Histological analysis showed leukocyte infiltration, dermal edema, and epidermal thickening at 1020 W/m² (24h and 72h post-exposure), with no significant changes below 765 W/m². These findings suggest localized quasi-MMW exposure may induce an inflammatory response, but the threshold appears to be at 1020 W/m², indicating effects only at high exposure levels.