Speaker
Description
The rapid progress in information and telecommunication technology has led to a significant increase in microwave radiation, making it a major source of environmental pollution. As a result, radiation protection is critical in our daily life and for those who work in the electromagnetic field. Of particular significance is the potential impact of microwave radiation on the central nervous system (CNS), several studies suggest a possible link between microwave radiation exposure and CNS alterations. Our research indicates that microwave radiation at 30mW/cm² can lead to an increased release of Brain-Derived Neurotrophic Factor (BDNF), which is accompanied by the upregulation of NMDAR and TrkB expression, as well as an increase in the expression of Cortactin and PSD 95 proteins, and enhanced neurotransmitter release. In contrast, microwave radiation at 50mW/cm² results in decreased BDNF release, downregulation of NMDAR and TrkB expression, reduced expression of Cortactin and PSD95 proteins, and diminished neurotransmitter release. The experimental results suggest that microwave radiation may influence synaptic transmission by modulating BDNF expression, which in turn regulates TrkB-pCREB and affects the expression of postsynaptic NMDAR, PSD 95, and Cortactin. Additionally, microwave radiation might regulate pCREB expression through its impact on NMDAR, and affecting the TrkB signaling pathway, finally establishing a bidirectional regulatory mechanism with BDNF. Furthermore, this research highlights the intricate interplay, thereby establishing candidate targets for developing preventive and treatment strategies to mitigate microwave radiation-induced damage.
