22–27 Jun 2025
Couvent des Jacobins
Europe/Paris timezone

Threshold Estimation of Nociceptive Small Fibers During Intraepidermal Electrical Stimulation - Modeling of Membrane and Synaptic properties-

25 Jun 2025, 11:15
15m
Les Dortoirs (Couvent des Jacobins)

Les Dortoirs

Couvent des Jacobins

Speaker

Akimasa Hirata

Description

This study examines Aδ- and C-fiber activation thresholds using intraepidermal electrical stimulation (IES) and computational modeling. Anodal stimulation activated Aδ-fibers with single pulses, while C-fibers required multiple pulses. Cathodal stimulation failed to activate C-fibers, indicating a higher perception threshold. Computational modeling validated experimental results, refining stimulation protocols for selective small-fiber activation. The findings contribute to neuropathic pain diagnostics and international neural stimulation guidelines.

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