"The field of biofabrication is continually growing due to the increasing life expectancy of humans. The most promising technique in this field is 3D bioprinting, nevertheless, there are still several limitations like low resolution, the challenging printing of hollow tubular structures with low wall thickness due to high shear rates, and low cell alignment. 4D biofabrication is a technique...
"Introduction
An osteochondral scaffold with a superficial collagen layer for cartilage replacement and a collagen/Magnesium-hydroxyapatite (Mg-HA) layer for bone replacement has demonstrated good clinical results in osteochondral defects [1]. However, subchondral bone repair remained suboptimal, with a long maturation time. In this study, we first confirmed the role of Mg-HA into the...
"Introduction
Bioresorbable stents (BRS) are designed to provide a temporary support to the vessel wall while the structure slowly degrades until completely resorbed. In order to prevent neointimal hyperplasia, antiproliferative drugs such as everolimus are loaded into stents, although endothelialization may be delayed due to long release periods [1]. Additive manufacturing (AM) and...
Introduction:
With the aim of restoring both the structure and the function of the damaged ureter, the most common medical approaches involve the use of autologous tissue or cells transplants. However, there are many complications that hamper a total or even partial ureter regeneration. Therefore, ureteral regeneration is still a medical unresolved challenge. In this field, electrospun...
"CONTROLLING CELL RESPONSES WITH SURFACE POTENTIAL ON ELECTROSPUN POLY(L-LACTIDE) (PLLA) SCAFFOLDS PRODUCED WITH POSITIVE AND NEGATIVE VOLTAGE POLARITY
Martyna Polak1*, Urszula Stachewicz1
1Faculty of Metals Engineering and Industrial Computer Science, AGH University of Science and Technology, Poland
*mpolak@agh.edu.pl
Abstract
Cell responses are essential for all tissue...
Development of degradable blood contacting devices (BCDs) is often associated not only with weak mechanical properties and high molecular weight of the degradation products, but also with long-term thrombogenicity issues. Poly(2-hydroxyethyl methacrylate) (pHEMA) emerges as a promising hydrogel to be used in BCDs mainly due to its bio/hemocompatibility and non-fouling character. However,...
"Introduction
Tympanic membrane perforations (TMP) represent a common cause of visit to the ENT clinic, usually due to recurrent infections or trauma. The rate of recovery for each perforation depends mainly on the size of the perforation and the secondary infections developed. Although most TMPs heal spontaneously, some patients can develop a chronic defect. The traditional technique used in...
"Introduction: Spider silk (SPSI) as one of nature’s most fascinating materials has attracted vivid attention due to its remarkable performance in tissue regenerative applications by supporting nerve growth and nerve regeneration. Particularly for supporting the regeneration of large nerve defects, the biomaterial has proven to be incomparably successful. The material’s variability and the...
"*Purpose/Objectives: Scaffolds with a tissue-like characteristics and suitable physical properties are critical for tissue engineering and regeneration. 2-hydroxyethyl methacrylate (HEMA) and methyl methacrylate (MMA) were commonly used for biomaterials because of their high biocompatibility and stability in the host tissue. Herein, we report porous poly(HEMA-co-MMA) scaffold for tissue...
"Introduction: Minimally-invasive prenatal interventions which aim to ameliorate fetal developmental defects have become a clinical reality and are currently performed for a variety of life-threatening complications. However, in up to 30% of the cases, the intervention translates into preterm birth and its associated negative consequences. The puncture created in the fetal membranes (FMs)...
"Introduction
It has been shown for many connective tissue types that substrate orientation can control collagen and ECM deposition. This has been used to engineer tissues with aligned fibril structures such as tendon. In cortical bone, collagen is organised into a lamellar structure with highly aligned collagen sheets packed into a “twisted plywood” configuration, however, reproducing this...
Introduction
Skeletal muscle (SM) tissue engineering aims to achieve a mature SM tissue in vitro, by combining precursor cells, suitable substrates and the right stimuli to facilitate cell growth and differentiation into the desired phenotype. In this field, polymeric thin films are attractive due to their small thickness (from hundreds of nm to some μm), flexibility, adhesiveness,...
"Introduction
Guided tissue regeneration (GTR) is a surgical procedure that specifically aims to regenerate soft and hard periodontal tissues when they are irreversibly destructed. GTR requires special porous barrier membranes, preferentially degradable, capable of preventing soft tissue infiltration into the bone defect and simultaneously supporting bone regeneration. The aim of this study...
"Oesophageal cancer is the sixth most fatal cancer in worldwide and often requires surgical removal alongside chemo- or radiotherapy. The surgical treatment options available are highly invasive and have a large impact on a patient's quality of life. Oesophageal tissue is complex and has poor regenerative capacity meaning further surgical repair is usually required after oesophagectomy, often...
"INTRODUCTION
Preterm birth one of the biggest complications in Obstetrics and is the case of life-long morbidities or even mortality of newborns. With advances in fetal therapy, the occurrence of operation-induced failures of fetal membranes (FM) ending in preterm birth is increasing. Responsible for this adverse outcome are the created defects in the FM that do not spontaneously heal....
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Cell-based tissue engineering is promising to create living functional tissue. The implanted cellular construct should be evenly distributed cells in the scaffold, maintain high cellular viability as well as mechanical properties in order to actively participate in the regenerative process. Cell-laden filament-like hydrogels have advantageous for tissue engineering and regeneration...
Generally, articular cartilage disorder at the junction mainly results from constantly repeated dynamic tension/compression effects with aging time. Piezoelectric materials can deliver variable electric signals analogous to native tissues such as bone and cartilage associated with extracellular matrix (ECM) materials. Thus, there is a high need of degradable piezoelectric scaffold, which...
