“ActiveLayers” is a platform technology for building medical multilayer films based on layer-by-layer technology. It is characterized by its biocompatibility, environmental friendliness, modularity and multi-functionality where it can be optimized and adjusted to treat several medical problems such as; chronic wounds, non-healing bone fractures, periodontal regeneration and postoperative...
"Introduction: In recent years new therapies, such as skin cell lines injection and bioengineered autologous skin substitutes (BASS) technology, have emerged to promote re-epithelialization of damaged areas such as cutaneous wounds and ulcers or to treat patients with severe burns. Antiseptics are commonly used during wound healing to avoid serious infections, but some of them could have the...
Electrospun fiber comprising bioactive substrates has potential to implant into the wound site as a reliable therapeutic approach in tissue regeneration. Here, electrospun polyvinyl alcohol conjugated tyramine (PVA-Tyr) and collagen (Col) fibrous mat containing chitosan nanoparticle loaded with epigallocatechin 3-gallate (NCs-EGCG) developed and the composite was applied to evaluate in vivo...
"Introduction
Chronic skin wounds place a high burden on patients and health systems. In this study, we developed a composite of an electrospun fleece and a freestanding multilayer film, to combine their respective advantages.
Methodology
A gelatin solution was electrospun and the resulting fleece partially crosslinked in formaldehyde vapor. Spray coating was employed to build up a...
"Introduction
Wisdom tooth extraction is one of the most common surgeries carried out in the UK, and is notorious for causing post-operative complications. 1 in 6 patients experience a condition called alveolar osteitis “dry-socket” after wisdom tooth removal; a condition where the blood clot is lost and the extraction socket becomes painful. The condition is a serious problem and causes a...
"Introduction: Severe skin lesions can be life-threatening conditions, especially in burnt patients. We recently described the UGRSKIN model of bioartificial human skin generated by tissue engineering as an ATMP1. Although preliminary clinical results are promising, the biofabrication procedure requires long periods of time due to the need of obtaining abundant keratinocyte cell populations...
"Introduction
Adipose-derived stem cell (ASC) are increasingly recognized as a vital tool for cell-based therapy. Hypoxic pre-conditioning of ASCs provides thier functional enhancement and makes the cells more attractive for translational science. Recently, ASCs from livestock animals have gained increased attention due to their promising role in developing regenerative medicine protocols...
"Introduction: Chronic wounds represent a major burden in human society, and their prevalence is expected to increase due to the upward trend of an aging population, incidence of diabetes, and obesity. In Europe, one out of five hospitalized patients suffers from a pressure ulcer. Moreover, the costs associated with its extensive care treatments are high; about 25 billion dollars are spent...
"Introduction. Impairment of extracellular matrix (ECM) remodeling is observed in tumour microenvironment or fibrosis and results in excessive collagen production and/or its decreased degradation by metalloproteinases (MMPs). Due to its pivotal role in tissue architectures and functions, ECM components and the proteins that regulate ECM remodeling are thus promising therapeutic targets for...
Keloids are abnormal scar tissue characterized by excessive proliferation of fibroblast and overabundance of collagen. The keloids often occur on earlobes, shoulders, back of the neck and the chest. To date, the therapeutic treatment of hypertrophic scar includes corticosteroid injection, laser therapy, cryotherapy, radiotherapy, and surgical scar revision. However, none of the above methods...
"Introduction
Wound healing is a complex process that involves numerous cell types, cytokines, chemokines, growth factors and extracellular matrix (ECM) components, which work synergistically to achieve healing1,2. When the healing process fails to proceed through the four physiological phases, the wound is referred to as a chronic wound1,2,4,5. Chronic wounds are a significant global...
"Burned skin wound treatment is one of the most expensive burdens on healthcare systems worldwide. The severity and extension of burn trauma could elevate the rate of hospitalization, and patients with burn wounds are especially vulnerable to infections. Burn injuries are very challenging to manage since it causes loss of the integrity of large portions of the skin, leading to major disability...
